Culturally and Linguistically Appropriate Vaccine Education

NCT06186206 | Completed

• 1 other identifier: 00123120
• Study Type: interventional
• Target: 900
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to test the effectiveness of culturally tailored social media campaigns and WhatsApp-based vaccine training for healthcare workers in increasing childhood routine and HPV vaccine confidence and uptake in mainly indigenous rural communities in Guatemala. Main Research Questions:

• Does a culturally tailored social media campaign, deployed via Facebook and geographically targeting randomly assigned communities, increase childhood routine and HPV vaccine confidence and uptake in mainly indigenous rural communities in Guatemala?
• Does WhatsApp-based vaccine training for community healthcare workers increase vaccine uptake in these communities? Participants in this study will be involved in the following tasks: Community Healthcare Worker WhatsApp Training: Community healthcare workers will participate in WhatsApp training sessions to enhance their knowledge and skills related to vaccine education and communication. Pre-Post Surveys: Surveys will be collected from individuals who are caretakers of children under 5 recruited from local health facilities. A total of 600 people will participate in the surveys (200 from each study arm and 200 pre-intervention). Surveys will be conducted in Spanish, K'iche', and Kaqchikel languages to compare vaccination uptake, hesitancy, and barriers/facilitators of vaccination. Researchers will compare the groups receiving the social media campaign and WhatsApp training to those with no intervention to determine the effects on childhood routine and HPV vaccine confidence and uptake in indigenous rural communities in Guatemala.

Conditions

Vaccine Hesitancy

Keywords

Vaccination; Indigenous Communities; Social Media Campaign; Guatemala

Outcome Measures

Primary Outcomes (2)

• Vaccination of children < 5 years

  Health facility clinic data about vaccinations for key under 5 years of age vaccinations and HPV. We will measure overall coverage of routine childhood vaccines (defined as having completed all recommended vaccines by age), as well as coverage by individual vaccine type. Caregiver report of childhood vaccinations in the last 3 months, collected via in person survey (yes/no responses to questions about specific recent vaccines given the age of the child)

  6 months

• Hesitancy for vaccination

  Caregiver report of childhood vaccination hesitancy, collected via in person survey. Collected using the Vaccine Hesitancy Scale, which has been validated in rural Guatemala for childhood vaccination

  2 months after intervention

Secondary Outcomes (1)

• Vaccine knowledge

  2 months after intervention

Study Arms (3)

Social Media Messaging Only

EXPERIMENTAL

In this arm of the clinical trial, four selected communities will receive a culturally tailored social media campaign designed to increase childhood routine and HPV vaccine confidence and uptake. The campaign will be deployed via Facebook and will geographically target these communities. This arm serves as the first intervention group.

Behavioral: Social media interventions for vaccine uptake

Social Media and Health Worker WhatsApp

EXPERIMENTAL

In this arm, another set of four communities will receive both the culturally tailored social media campaign (deployed via Facebook) and WhatsApp-based vaccine training for community healthcare workers. This arm serves as the second intervention group.

Behavioral: Social media interventions for vaccine uptake

No Intervention (Control)

NO INTERVENTION

Interventions

Social media interventions for vaccine uptake BEHAVIORAL

Culturally Tailored Social Media Campaign: 4 communities receive a culturally tailored social media campaign via Facebook, focusing on geographical targeting. Content aligns with indigenous cultural norms and values, featuring educational materials, testimonials, and messaging addressing vaccine misconceptions on childhood routine and HPV vaccinations' importance and safety. WhatsApp-Based Vaccine Training for CHW: 4 communities receive both the culturally tailored social media campaign and WhatsApp-based vaccine training for CHWs. Interactive training allows CHWs to engage in discussions, seek guidance, and enhance their ability to communicate effectively. This component targets vaccine hesitancy and boosts vaccine uptake rates.

Social Media Messaging Only; Social Media and Health Worker WhatsApp

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• speaks a local language,
• live in the area,
• over age 18 and
• cares for a child 5 years or younger

You may not qualify if:

• Not an adult,
• not on social media

Sponsors & Collaborators

• University of California, San Francisco: lead
• Stanford University: collaborator
• Wuqu' Kawoq, Maya Health Alliance: collaborator

Study Sites (1)

Maya Health Alliance | Wuqu' Kawoq

Tecpán Guatemala, Departamento de Chimaltenango, Guatemala

Location

MeSH Terms

Conditions

Vaccination Hesitancy

Condition Hierarchy (Ancestors)

Vaccination Refusal; Treatment Refusal; Treatment Adherence and Compliance; Health Behavior; Behavior

Study Officials

• Nadia Diamond-Smith, PhD, MS

  University of California, San Francisco

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 15, 2023
• First Posted: December 29, 2023
• Study Start: January 5, 2024
• Primary Completion: March 15, 2024
• Study Completion: March 15, 2024
• Last Updated: March 20, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

GU (1)