NCT05582564

Brief Summary

COVID-19 vaccine hesitancy can be observed at different rates in different countries. 1,068 people were surveyed in France and Italy to inquire about individual potential acceptance, focusing on time preferences, in a risk-return framework: having the vaccination today, in a month, and in 3 months; perceived risks of vaccination and COVID-19; and expected benefit of the vaccine. A randomized controlled trial was conducted to understand how everyday stimuli, such as fact-based news about vaccines, impact on audience acceptance of vaccination. The main experiment involved two groups of participants and two different articles about vaccine-related thrombosis taken from two Italian newspapers. One article used a more abstract description and language, and the other used a more anecdotical description and concrete language; each group read only one of these articles. Two other groups were assigned categorization tasks; one was asked to complete a concrete categorization task and the other an abstract categorization task.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,068

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jun 2021

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 2, 2021

Completed
18 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 20, 2021

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

January 31, 2022

Completed
9 months until next milestone

First Submitted

Initial submission to the registry

October 13, 2022

Completed
4 days until next milestone

First Posted

Study publicly available on registry

October 17, 2022

Completed
Last Updated

October 17, 2022

Status Verified

October 1, 2022

Enrollment Period

18 days

First QC Date

October 13, 2022

Last Update Submit

October 13, 2022

Conditions

Keywords

vaccine hesitancy

Outcome Measures

Primary Outcomes (1)

  • vaccine hesitancy; number of participants accepting the vaccination

    revealed preferences

    same day

Study Arms (5)

concrete text

OTHER

Italian and French unvaccinated cohorts (n= 164; n=163)

Other: abstract vs concrete texts

abstract text

OTHER

Italian and French unvaccinated cohorts (n=155; n=153)

Other: abstract vs concrete texts

abstract task

OTHER

Italian and French unvaccinated cohorts (n=54; n=55)

Other: abstract vs concrete texts

concrete task

OTHER

Italian and French unvaccinated cohorts (n=55; n=56)

Other: abstract vs concrete texts

control

OTHER

Italian and French unvaccinated cohorts (n=103; n=110)

Other: abstract vs concrete texts

Interventions

The main experiment involved two groups of participants and two different articles about vaccine-related thrombosis taken from two Italian newspapers. One article used a more abstract descriptive style and language, while the other used a more anecdotical style and concrete language: each group read only one of these articles. Both articles are the same length and describe an episode of vaccine-related thrombosis. The abstract text uses a more formal and impersonal language, reporting more scientific considerations; the concrete text uses a more familiar and emotional style and provides a more anecdotical description of the case. Texts were also weighted according to a concreteness semantic vocabulary. French received translated versions.Two other groups were assigned categorization tasks; one was asked to complete a concrete categorization task and the other an abstract categorization task.

Also known as: abstract vs concrete tasks
abstract taskabstract textconcrete taskconcrete textcontrol

Eligibility Criteria

Age18 Years - 64 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • unvaccinated individuals

You may not qualify if:

  • vaccinated individuals

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Bari Aldo Moro

Bari, 70121, Italy

Location

Related Publications (4)

  • Liberman N, Trope Y. Traversing psychological distance. Trends Cogn Sci. 2014 Jul;18(7):364-9. doi: 10.1016/j.tics.2014.03.001. Epub 2014 Apr 10.

    PMID: 24726527BACKGROUND
  • Trope Y, Liberman N. Temporal construal. Psychol Rev. 2003 Jul;110(3):403-21. doi: 10.1037/0033-295x.110.3.403.

    PMID: 12885109BACKGROUND
  • Loomba S, de Figueiredo A, Piatek SJ, de Graaf K, Larson HJ. Measuring the impact of COVID-19 vaccine misinformation on vaccination intent in the UK and USA. Nat Hum Behav. 2021 Mar;5(3):337-348. doi: 10.1038/s41562-021-01056-1. Epub 2021 Feb 5.

    PMID: 33547453BACKGROUND
  • MacDonald NE; SAGE Working Group on Vaccine Hesitancy. Vaccine hesitancy: Definition, scope and determinants. Vaccine. 2015 Aug 14;33(34):4161-4. doi: 10.1016/j.vaccine.2015.04.036. Epub 2015 Apr 17.

    PMID: 25896383BACKGROUND

MeSH Terms

Conditions

Vaccination Hesitancy

Condition Hierarchy (Ancestors)

Vaccination RefusalTreatment RefusalTreatment Adherence and ComplianceHealth BehaviorBehavior

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

October 13, 2022

First Posted

October 17, 2022

Study Start

June 2, 2021

Primary Completion

June 20, 2021

Study Completion

January 31, 2022

Last Updated

October 17, 2022

Record last verified: 2022-10

Data Sharing

IPD Sharing
Will not share

No personal data have been collected. Individual responses to the questionnaire will be shared without personal information of respondents on a public repository.

Locations