Anterior Segment Anatomic Parameters for Risk Profiling of Primary Angle-closure Glaucoma

NCT06143943 | Completed

• 1 other identifier: 20231116
• Study Type: observational
• Target: 168
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to examine the anterior segment anatomical parameters associated with the scleral spur and cornea for risk profiling of primary angle-closure glaucoma (PACG). The main question it aims to answer is: • Are there new anatomical parameters of the anterior segment of the eye that can be used early for risk profiling for PACG? Researchers will compare PACG and narrow angle groups to see if there are some anatomical parameters that can distinguish the two.

Conditions

Glaucoma, Angle-Closure

Outcome Measures

Primary Outcomes (1)

• Trabecular scleral-spur angle

  The angle between the line of the corneal endothelium 750 μm from the scleral spur to the scleral spur and the bilateral line of the scleral spur

  2022-11-22 to 2022-12.31

Study Arms (2)

primary angle-closure glaucoma

narrow angle

Eligibility Criteria

• Age: 30 Years - 92 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with PACG and anterior chamber angle stenosis were enrolled in this study and excluded from other diseases affecting the structure of the anterior segment of the eye, as well as a history of intraocular surgery.

You may qualify if:

• Primary angle-closure glaucoma （PACG) was defined as an occlusion angle with peripheral anterior synechiae and intraocular pressure (IOP) \> 21 mmHg or associated with glaucomatous optic neuropathy. The following conditions were identified as possible glaucomatous optic neuropathies, including a vertical cup-to-disc ratio ≥ 0.6, vertical cup-to-disc ratio asymmetry ≥ 0.2, optic disc haemorrhage, and visible retinal nerve fibre layer defect.

You may not qualify if:

• (1) severe systemic disease, (2) secondary angle-closure glaucoma, (3) other ocular diseases, (4) history of intraocular surgery, and (5) unclear examination images.

Sponsors & Collaborators

• Min Ke: lead

Study Sites (1)

Zhongnan Hospital of Wuhan University

Wuhan, Hubei, 430071, China

Location

MeSH Terms

Conditions

Glaucoma, Angle-Closure

Condition Hierarchy (Ancestors)

Glaucoma; Ocular Hypertension; Eye Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor of Treatment

Study Record Dates

• First Submitted: November 16, 2023
• First Posted: November 22, 2023
• Study Start: November 22, 2022
• Primary Completion: December 31, 2022
• Study Completion: February 28, 2023
• Last Updated: November 22, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)