Acute on Chronic Liver Failure in Cirrhotic Patients at Assiut University Hospitals
Incidence and Outcomes of Acute on Chronic Liver Failure (ACLF) in Cirrhotic Patients at Assiut University Hospitals
1 other identifier
observational
96
0 countries
N/A
Brief Summary
ACLF is a distinct syndrome that is different from chronic progressive hepatic decompensation. In most cases of ACLF, patients present initially with clinical manifestations of a decompensating event, usually renal impairment, worsening of abdominal ascites, jaundice or Hepatic encephalopathy (HE) and often precipitated by bacterial infection.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Dec 2023
Typical duration for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 14, 2023
CompletedFirst Posted
Study publicly available on registry
November 22, 2023
CompletedStudy Start
First participant enrolled
December 1, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2026
ExpectedNovember 22, 2023
November 1, 2023
1 month
September 14, 2023
November 18, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
CHILD Pugh score
Child-Pugh A: 5 to 6 points. Child-Pugh B: 7 to 9 points. Child-Pugh C: 10 to 15 points.
baseline
Secondary Outcomes (1)
ACLF score ( acute on chronic liver failure score )
baseline
Interventions
Laboratory tests inform of Complete blood count , liver function tests , kidney function tests abdominal ultrasound
Eligibility Criteria
all patients with liver cirrhosis
You may qualify if:
- all cirrhotic patients who will be admitted to our intensive care unit in our hospital meeting the criteria of defention of ACLF according to the CANONIC trial and The European Association for the Study of the Liver graded with chronic liver failure organ failure scor ( CLIF-OF )
You may not qualify if:
- children less than 16 years 2- adult more than 70 years 3- patients with Hepatocellular carcinoma 4- patients known to be Chronic kidney disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Arroyo V, Moreau R, Kamath PS, Jalan R, Gines P, Nevens F, Fernandez J, To U, Garcia-Tsao G, Schnabl B. Acute-on-chronic liver failure in cirrhosis. Nat Rev Dis Primers. 2016 Jun 9;2:16041. doi: 10.1038/nrdp.2016.41.
PMID: 27277335RESULT
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
DR.Effat Abdl hady El tony, doctor
CONTACT
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principle invistegator
Study Record Dates
First Submitted
September 14, 2023
First Posted
November 22, 2023
Study Start
December 1, 2023
Primary Completion
January 1, 2024
Study Completion (Estimated)
October 1, 2026
Last Updated
November 22, 2023
Record last verified: 2023-11