NCT05909319

Brief Summary

Acute-on-chronic liver failure (ACLF) refers to the acute deterioration of liver function in patients with chronic liver disease. Neutrophils are a major component of the innate immune system, and previous studies have revealed enhanced production of neutrophil extracellular traps (NETs) in ACLF. However, there is still a lack of systematic research on the correlation between NETs and the prognosis of ACLF. We screened NETs related biomarkers through bioinformatics analysis, which play an important role in the diagnosis of ACLF. This study will explore whether these NETs related biomarkers also play an important role in the prognosis of ACLF and further investigate their role in the pathogenesis of ACLF.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
200

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jun 2023

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 29, 2023

Completed
20 days until next milestone

First Posted

Study publicly available on registry

June 18, 2023

Completed
7 days until next milestone

Study Start

First participant enrolled

June 25, 2023

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 25, 2024

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 25, 2025

Completed
Last Updated

June 18, 2023

Status Verified

April 1, 2023

Enrollment Period

1.5 years

First QC Date

May 29, 2023

Last Update Submit

June 11, 2023

Conditions

Acute-On-Chronic Liver Failure

Keywords

Neutrophil extracellular traps

Outcome Measures

Primary Outcomes (3)

  • mortality

    mortality of patients with ACLF

    30 days

  • mortality

    mortality of patients with ACLF

    90 days

  • mortality

    mortality of patients with ACLF

    half a year

Study Arms (1)

ACLF

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients who meet the diagnostic criteria of Chinese Group on the Study of Severe Hepatitis B (COSSH) for acute-on-chronic liver failure

You may qualify if:

  • \. Patients who meet the diagnostic criteria of Chinese Group on the Study of Severe Hepatitis B (COSSH) for acute-on-chronic liver failure

You may not qualify if:

  • Age greater than 75 years old
  • liver cancer
  • previous liver transplantation
  • other serious extrahepatic organ diseases
  • uncontrolled bacterial infections.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Acute-On-Chronic Liver Failure

Condition Hierarchy (Ancestors)

Liver Failure, AcuteLiver FailureHepatic InsufficiencyLiver DiseasesDigestive System Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 29, 2023

First Posted

June 18, 2023

Study Start

June 25, 2023

Primary Completion

December 25, 2024

Study Completion

June 25, 2025

Last Updated

June 18, 2023

Record last verified: 2023-04