Pattern of Acute on Chronic Liver Failure in Patient With HCV Related Chronic Liver Disease

NCT03456518 | Completed

• 1 other identifier: POACLIFWHCV LC
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 2

Brief Summary

The concept of acute-on-chronic liver failure (ACLF) was introduced by Jalan and Williams in 2002 to describe the acute deterioration in liver function over 2 to 4 weeks in a patient with well-compensated cirrhosis associated with a precipitating event (hepatotoxic: superimposed hepatitis viral infection, drug-induced liver injury, hepatotoxins, or excessive alcohol consumption; extra hepatic: variceal bleeding or sepsis), leading to severe deterioration in clinical status with jaundice and hepatic encephalopathy and/or HRS. Following this concept, several proposals for the diagnostic criteria of ACLF have been suggested.

Conditions

Acute-On-Chronic Liver Failure

Outcome Measures

Primary Outcomes (1)

• pattern of acute on chronic liver cell failure

  evaluation of cases with acute on chronic liver cell failure as number of cases diagnosed with ACLF in this period , the precipitating factor of the condition , the fate of the patient (improving or deterioration or death ) in the 28 days following diagnosis .

  march 2018 to march 2019

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

CLD patients with HCV related etiology who will admitted to our hospital with picture of acute decompensation and deterioiration of pre-existing liver condition (defined by the development of ascites, encephalopathy, gastrointestinal haemorrhage and/or bacterial infection) associated with either a single organ failure (single renal failure or other single non-renal organ failure if associated with renal and/or brain dysfunction) or multiple organ failures) to meet the criteria of EASL-CLIF definition .

You may qualify if:

• Adult Patients with HCV related CLD based on clinical, biochemical and imaging evidence., with or without prior decompensation.
• Patients diagnosed to have ACLIF at any grade (1-3)

You may not qualify if:

• Acute liver failure without evidence of chronic liver disease.
• Other etiology of chronic liver disease
• Patients diagnosed with no ACLIF No ACLF
• This category includes patients who either:
• Do not have any organ failure
• Have a single organ failure that does not involve the kidney with a serum creatinine level of \<1.5 mg per dl and no hepatic encephalopathy
• Have a single brain failure with a serum creatinine level of \<1.5 mg per dl
• Patients refuse to participate.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (2)

Al-Rajhi Liver Hospital, Assiut University

Asyut, 71515, Egypt

Location

Al-Rajhi liver hospital ,Assiut university

Asyut, Egypt

Location

Related Publications (1)

• Gines P, Quintero E, Arroyo V, Teres J, Bruguera M, Rimola A, Caballeria J, Rodes J, Rozman C. Compensated cirrhosis: natural history and prognostic factors. Hepatology. 1987 Jan-Feb;7(1):122-8. doi: 10.1002/hep.1840070124.

  PMID: 3804191 BACKGROUND

MeSH Terms

Conditions

Acute-On-Chronic Liver Failure

Condition Hierarchy (Ancestors)

Liver Failure, Acute; Liver Failure; Hepatic Insufficiency; Liver Diseases; Digestive System Diseases

Study Officials

• Mohammed Medhat

  Al-Arajhy Liver Hospital, Assiut University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident doctor

Study Record Dates

• First Submitted: February 23, 2018
• First Posted: March 7, 2018
• Study Start: November 1, 2018
• Primary Completion: October 31, 2019
• Study Completion: November 30, 2019
• Last Updated: January 23, 2020

Record last verified: 2020-01

Locations

EG (2)