NCT06129513

Brief Summary

Dietary protein ingestion is required to maximise the anabolic response during the recovery from resistance exercise. Whey protein is considered the optimal dietary strategy to maximise post-exercise muscle protein synthesis, but animal-protein production and consumption is associated with growing environmental and ethical concerns. Plant-based protein sources are considered of lesser anabolic quality than isonitrogenous boluses of animal-derived protein attributed to, at least in part, deficiencies in key essential amino acid. Blending different protein sources may overcome amino acid deficiencies and potentiate the post-exercise anabolic response. In the present study the investigators assessed the post-exercise muscle protein synthetic response following the ingestion of a novel plant-based protein isolate when compared with an isonitrogenous bolus of whey protein in healthy young, resistance trained women and men.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Feb 2022

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 24, 2022

Completed
8 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 31, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 31, 2022

Completed
11 months until next milestone

First Submitted

Initial submission to the registry

September 20, 2023

Completed
2 months until next milestone

First Posted

Study publicly available on registry

November 13, 2023

Completed
Last Updated

November 13, 2023

Status Verified

November 1, 2023

Enrollment Period

8 months

First QC Date

September 20, 2023

Last Update Submit

November 8, 2023

Conditions

Muscle Metabolism

Keywords

Myofibrillar Protein SynthesisResistance ExercisePlant ProteinStable Isotopes

Outcome Measures

Primary Outcomes (1)

  • Post-exercise myofibrillar protein synthesis following protein ingestion

    The fractional synthetic rate of myofibrillar proteins

    4 hours

Secondary Outcomes (4)

  • Post-exercise myofibrillar protein synthesis during the early postprandial period

    2 hours

  • Post-exercise myofibrillar protein synthesis during the late postprandial period

    2 hours

  • Plasma amino acid response

    4 hours

  • Serum insulin response

    4 hours

Study Arms (2)

Whey protein isolate

ACTIVE COMPARATOR

Following a bout of bilateral resistance exercise, participants will ingest 32 g protein from whey protein isolate

Behavioral: Bilateral resistance exerciseDietary Supplement: Whey protein

Plant-blend isolate

EXPERIMENTAL

Following a bout of bilateral resistance exercise, participants will ingest 32 g protein from a novel plant-blend protein isolate

Behavioral: Bilateral resistance exerciseDietary Supplement: Plant-blend protein

Interventions

Bilateral resistance exerciseBEHAVIORAL

A bout of bilateral resistance exercise consisting of barbell back squat, leg leg press and leg extension

Plant-blend isolateWhey protein isolate
Whey proteinDIETARY_SUPPLEMENT

Following execution of bilateral resistance exercise, participants will ingest 32 g protein from whey protein isolate

Whey protein isolate
Plant-blend proteinDIETARY_SUPPLEMENT

Following execution of bilateral resistance exercise, participants will ingest 32 g protein from plant-blend protein isolate

Plant-blend isolate

Eligibility Criteria

Age18 Years - 40 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • BMI between 18 - 30
  • Resistance trained (\>3 times per week structured resistance exercise training for at least 3 months)

You may not qualify if:

  • Any metabolic impairment
  • Any cardiovascular impairment
  • Smoking
  • Lactose intolerance
  • Allergies to products containing dairy, meat or nuts
  • Prescribed intake of over the counter pharmaceuticals

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Exeter

Exeter, United Kingdom

Location

Related Publications (1)

  • VAN DER Heijden I, Monteyne AJ, West S, Morton JP, Langan-Evans C, Hearris MA, Abdelrahman DR, Murton AJ, Stephens FB, Wall BT. Plant Protein Blend Ingestion Stimulates Postexercise Myofibrillar Protein Synthesis Rates Equivalently to Whey in Resistance-Trained Adults. Med Sci Sports Exerc. 2024 Aug 1;56(8):1467-1479. doi: 10.1249/MSS.0000000000003432. Epub 2024 Mar 23.

    PMID: 38537270DERIVED

MeSH Terms

Interventions

Whey Proteins

Intervention Hierarchy (Ancestors)

Milk ProteinsAnimal Proteins, DietaryDietary ProteinsProteinsAmino Acids, Peptides, and ProteinsWheyMilkDairy ProductsFoodDiet, Food, and NutritionPhysiological PhenomenaFood and Beverages

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 20, 2023

First Posted

November 13, 2023

Study Start

February 24, 2022

Primary Completion

October 31, 2022

Study Completion

October 31, 2022

Last Updated

November 13, 2023

Record last verified: 2023-11

Locations

GB(1)