Protein and Exercise-Induced Gastrointestinal Symptoms

NCT05855174 | Completed

• 1 other identifier: MountRoyalU
• Study Type: interventional
• Target: 13
• Locations: 1 country
• Sites: 1

Brief Summary

Recommendations for carbohydrate intakes in the pre-exercise meal for endurance athletes are available; however, are lacking protein. Therefore, the purpose of this study is to quantify exercise-induced gastrointestinal symptoms and gut fullness occurring in response to a low protein (control) and a high protein (intervention) pre-exercise meal. The secondary purpose is to quantify blood glucose responses to a high-protein pre-exercise meal as compared to a low-protein control.

Conditions

Gastro-Intestinal Disorder

Keywords

Dietary protein; Runners; Gastrointestinal symptoms

Outcome Measures

Primary Outcomes (2)

• Self-report exercise induced gastrointestinal symptoms

  Quantify exercise induced gastrointestinal symptoms via a 0-9 point Likert scale questionnaire including 6 questions for upper abdominal problems, 7 questions for lower abdominal problems and 5 systemic problems. Likert scale questions are administered at fasting, pre-exercise and post-exercise. Questionnaires are administered in response to a low protein (control) and a high protein pre-exercise meal.

  3 hours per session

• Gut fullness

  Gut fullness measured using a 100mm visual analogue scale anchored by not full at all and very full at fasting 15, 30 and 60 minutes post-meal and post run. Questionnaires are administered in response to a low protein (control) and a high protein pre-exercise meal.

  3 hours per session

Secondary Outcomes (2)

• Plasma glucose levels

  3 hours per session

• Perceive exertion

  1 hour per session

Study Arms (2)

Low Protein

ACTIVE COMPARATOR

Protein intake at 0.15g/kg body weight

Dietary Supplement: Whey protein

High Protein

EXPERIMENTAL

Protein intake at 0.4 g/kg body weight

Dietary Supplement: Whey protein

Interventions

Whey protein DIETARY_SUPPLEMENT

Weight protein provided in a shake with carbohydrate and water

High Protein; Low Protein

Eligibility Criteria

• Age: 18 Years - 59 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• recreational competitive runners, defined as running at least 25 km per week
• experiences exercise-induced gastrointestinal symptoms while running

You may not qualify if:

• individuals with food allergies,
• gastrointestinal disorders (e.g., celiac disease, irritable bowl syndrome, etc.)
• adherence to a special diet
• pregnancy
• pre-existing medical condition that would prevent them from completing the prescribed exercise
• blood-borne illness

Sponsors & Collaborators

• Mount Royal University: lead

Study Sites (1)

Mount Royal University

Calgary, Alberta, T3E 6K6, Canada

Location

Related Publications (6)

• Briggs MA, Harper LD, McNamee G, Cockburn E, Rumbold PLS, Stevenson EJ, Russell M. The effects of an increased calorie breakfast consumed prior to simulated match-play in Academy soccer players. Eur J Sport Sci. 2017 Aug;17(7):858-866. doi: 10.1080/17461391.2017.1301560. Epub 2017 Mar 21.

  PMID: 28323574 BACKGROUND

• Costa RJS, Snipe RMJ, Kitic CM, Gibson PR. Systematic review: exercise-induced gastrointestinal syndrome-implications for health and intestinal disease. Aliment Pharmacol Ther. 2017 Aug;46(3):246-265. doi: 10.1111/apt.14157. Epub 2017 Jun 7.

  PMID: 28589631 BACKGROUND

• Kerksick CM, Arent S, Schoenfeld BJ, Stout JR, Campbell B, Wilborn CD, Taylor L, Kalman D, Smith-Ryan AE, Kreider RB, Willoughby D, Arciero PJ, VanDusseldorp TA, Ormsbee MJ, Wildman R, Greenwood M, Ziegenfuss TN, Aragon AA, Antonio J. International society of sports nutrition position stand: nutrient timing. J Int Soc Sports Nutr. 2017 Aug 29;14:33. doi: 10.1186/s12970-017-0189-4. eCollection 2017.

  PMID: 28919842 BACKGROUND

• Parnell JA, Wagner-Jones K, Madden RF, Erdman KA. Dietary restrictions in endurance runners to mitigate exercise-induced gastrointestinal symptoms. J Int Soc Sports Nutr. 2020 Jun 10;17(1):32. doi: 10.1186/s12970-020-00361-w.

  PMID: 32522222 BACKGROUND

• Pfeiffer B, Stellingwerff T, Hodgson AB, Randell R, Pottgen K, Res P, Jeukendrup AE. Nutritional intake and gastrointestinal problems during competitive endurance events. Med Sci Sports Exerc. 2012 Feb;44(2):344-51. doi: 10.1249/MSS.0b013e31822dc809.

  PMID: 21775906 BACKGROUND

• Thomas DT, Erdman KA, Burke LM. Position of the Academy of Nutrition and Dietetics, Dietitians of Canada, and the American College of Sports Medicine: Nutrition and Athletic Performance. J Acad Nutr Diet. 2016 Mar;116(3):501-528. doi: 10.1016/j.jand.2015.12.006.

  PMID: 26920240 BACKGROUND

MeSH Terms

Conditions

Digestive System Diseases

Interventions

Whey Proteins

Intervention Hierarchy (Ancestors)

Milk Proteins; Animal Proteins, Dietary; Dietary Proteins; Proteins; Amino Acids, Peptides, and Proteins; Whey; Milk; Dairy Products; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Officials

• Jill A Parnell, PhD

  Mount Royal University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: In this single-blinded crossover design, the participants will be blinded to which intervention the participants are receiving (i.e., high protein or low protein drinks).
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Crossover intervention; all participants will have a low protein and a high protein session.

Study Record Dates

• First Submitted: March 22, 2023
• First Posted: May 11, 2023
• Study Start: March 13, 2019
• Primary Completion: December 21, 2023
• Study Completion: December 21, 2023
• Last Updated: March 21, 2024

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)