Effect of Hyperbaric Oxygen Therapy

NCT06112210 | Completed

• 1 other identifier: HBstudy
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this tudy will be to investigate the effects of a single session of hyperbaric oxygen therapy (HBOT) on recovery and performance after a football match in elite youth football players. The main questions this study will aim to answer are: Will a single session of HBOT improve recovery parameters such as biochemical markers and physical fitness in elite youth football players after a football match? Will a single session of HBOT enhance the performance of elite youth football players after a football match? Participants in this study will include twenty elite youth male football players. They will be randomly assigned to either the HBOT group or the control group. All participants will undergo evaluations for biochemical parameters, physical fitness tests, and the Hooper Index (HI) at multiple time points: before the match, at the end of the match, one hour after the HBOT session, and 12 hours after the HBOT session. In the HBOT group, participants will receive 100% oxygen under elevated pressure in a hyperbaric chamber for a duration of 70 minutes immediately after the football match. Meanwhile, the control group will be exposed to normal atmospheric pressure. Biochemical analysis will involve collecting blood samples to measure markers such as myoglobin, creatine kinase, lactate dehydrogenase, alanine aminotransferase, and aspartate aminotransferase. Physical fitness tests will include vertical jump height measurements (squat jump, countermovement jump, and countermovement jump with arm swing) and linear speed assessments at various distances (5 m, 10 m, and 20 m). The Hooper Index (HI) will be used for subjective assessment of fatigue and well-being. This study aims to provide insights into the potential benefits of HBOT as a recovery strategy for elite youth football players and its impact on performance in the future.

Conditions

Performance Enhancing Product Use; Physical Fitness; Recovery; Sport

Keywords

hyperbaric chamber; football; recovery; hyperbaric oxygen therapy; performance; fatigue

Outcome Measures

Primary Outcomes (5)

• Myoglobin

  Measure of myoglobin concentration in blood. Myoglobin will be determined using Siemens IMMULITE 1000 (Siemens Healthcare Diagnostics, UK).

  baseline, 3 hours, 5 hours, 24 hours

• Creatine kinase

  Measure of creatine kinase concentration in blood. It will be analyzed using a biochemistry analyzer (A25 Biosystems Chemistry Analyzer).

  baseline, 3 hours, 5 hours, 24 hours

• Lactate dehydrogenase

  Measure of lactate dehydrogenase concentration in blood. It will be analyzed using a biochemistry analyzer (A25 Biosystems Chemistry Analyzer).

  baseline, 3 hours, 5 hours, 24 hours

• Alanine aminotransferase

  Measure of alanine aminotransferase concentration in blood. It will be analyzed using a biochemistry analyzer (A25 Biosystems Chemistry Analyzer).

  baseline, 3 hours, 5 hours, 24 hours

• Aspartate aminotransferase

  Measure of aspartate aminotransferase concentration in blood. It will be analyzed using a biochemistry analyzer (A25 Biosystems Chemistry Analyzer).

  baseline, 3 hours, 5 hours, 24 hours

Secondary Outcomes (6)

• Squat jump

  baseline, 3 hours, 5 hours, 24 hours

• Countermovement jump

  baseline, 3 hours, 5 hours, 24 hours

• Countermovement jump with arm swing

  baseline, 3 hours, 5 hours, 24 hours

• 5 meter linear speed

  baseline, 3 hours, 5 hours, 24 hours

• 10 meter linear speed

  baseline, 3 hours, 5 hours, 24 hours

Study Arms (2)

HBOT group

EXPERIMENTAL

Other: HBOT group

CON group

PLACEBO COMPARATOR

Other: CON group

Interventions

HBOT group OTHER

The HBOT will be performed in a Barox HBOT chamber (Yaklasim Makina San. Ve Tic. Ltd. Sti). Participants will be taken to the chamber immediately after the football match, where they will sit in individual chairs, and oxygen will be delivered through individual masks. The HBOT group will be exposed to 100% oxygen at 2.2 ATA (atmospheres absolute). Session will last 70 minutes.

HBOT group

CON group OTHER

The placebo protocols will be performed in a Barox HBOT chamber (Yaklasim Makina San. Ve Tic. Ltd. Sti). Participants will be taken to the chamber immediately after the football match, where they will sit in individual chairs, and oxygen will be delivered through individual masks. The CON group will be exposed to normobaric ambient pressure (1 ATA). The session will last 70 minutes.

Also known as: Control, Placebo

CON group

Eligibility Criteria

• Age: 16 Years - 18 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• football player
• free of injuries
• free of medical conditions contraindicated by hyperbaric oxygen therapy (HBOT)
• written parental consent

You may not qualify if:

• pre-existing injuries or medical conditions that are contraindicated by hyperbaric oxygen therapy (HBOT)
• participation in severe physical activity within 24 hours before the study
• participants who do not comply with the requirement to abstain from breakfast, caffeine, and alcohol prior to the first blood collection
• an active respiratory illness, such as a cold, at the time of the study

Sponsors & Collaborators

• University Medical Centre Ljubljana: lead

Study Sites (1)

Hyperbaric center Subotica

Subotica, Serbia

Location

MeSH Terms

Conditions

Fatigue

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 18, 2023
• First Posted: November 1, 2023
• Study Start: May 20, 2023
• Primary Completion: June 4, 2023
• Study Completion: June 6, 2023
• Last Updated: November 1, 2023

Record last verified: 2023-10

Locations

SE (1)