Effect of Exercise on Appetite in Response to Meals

NCT06096233 | Recruiting

• 1 other identifier: 200220449
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

This clinical trial's primary aim is to investigate the acute effect of two exercise bouts (short \[10 minutes\] and long \[30 minutes\]) on appetite and appetite-regulatory hormone responses to a standard meal test. The secondary aim is to investigate when the changes in appetite and appetite-regulatory hormones occur during exercise. As an exploratory aim, the researchers will test if the two exercise bouts influence ad libitum energy intake in the periods after the standard meal test. The researchers will compare three groups (control, short exercise, and prolonged exercise) to see if the exercise bouts affect appetite, appetite-regulatory hormones, and energy intake in healthy men.

Conditions

Healthy

Outcome Measures

Primary Outcomes (4)

• Change in Peptide-YY (PYY)

  Blood samples will be drawn at different time points during the trial to measure the change in PYY blood levels. Area under the plasma concentration versus time curve (AUC) of PYY will be calculated using the trapezoidal rule.

  At 0 (baseline), 0.167, 0.5, 1, 1.5, 2, 3, and 4 hours

• Change in Ghrelin

  Blood samples will be drawn at different time points during the trial to measure the change in ghrelin blood levels. Area under the plasma concentration versus time curve (AUC) of ghrelin will be calculated using the trapezoidal rule.

  At 0 (baseline), 0.167, 0.5, 1, 1.5, 2, 3, and 4 hours

• Change in Glucagon-Like Peptide-1 (GLP-1)

  Blood samples will be drawn at different time points during the trial to measure the change in GLP-1 blood levels. Area under the plasma concentration versus time curve (AUC) of GLP-1 will be calculated using the trapezoidal rule.

  At 0 (baseline), 0.167, 0.5, 1, 1.5, 2, 3, and 4 hours

• Change in subjective appetite sensations

  The subjective appetite sensations will be assessed using 100 mm visual analog scales (VAS) to measure appetite sensations (hunger, satiety, fullness, prospective food consumption, and desire to eat). The VAS are 100 mm long, with words anchored at each end expressing the most positive and negative ratings. Scores for each appetite construct range from 0-100.

  At 0 (baseline), 0.167, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 5.5, and 6 hours

Secondary Outcomes (2)

• Energy Intake

  At 5 hours

• Macro-nutrient Intake

  At 5 hours

Study Arms (3)

Control

NO INTERVENTION

The participants will not perform any exercise.

Short Exercise

EXPERIMENTAL

The participants will run on the treadmill for 10 minutes.

Other: Bouts of Exercise

Prolonged Exercise

EXPERIMENTAL

The participants will run on the treadmill for 30 minutes.

Other: Bouts of Exercise

Interventions

Bouts of Exercise OTHER

The participants will run on the treadmill for 10 minutes (short) or 30 minutes (prolonged).

Prolonged Exercise; Short Exercise

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Males aged 18 years or older.
• Have stable body mass for at least six months (within ±2 kg).

You may not qualify if:

• Females
• People who are younger than 18 or older than 65 years old.
• Have food allergies.
• Have significant contraindications to exercise (e.g., an injury that would inhibit running).
• Smoking.
• Suffering from metabolic health issues, e.g., history of diabetes, cardiovascular disease, or eating disorders.

Sponsors & Collaborators

• University of Glasgow: lead
• Northern Border University: collaborator

Study Sites (1)

New Lister Building at Glasgow Royal Infirmary

Glasgow, G31 2ER, United Kingdom

RECRUITING

Related Publications (2)

• Broom DR, Miyashita M, Wasse LK, Pulsford R, King JA, Thackray AE, Stensel DJ. Acute effect of exercise intensity and duration on acylated ghrelin and hunger in men. J Endocrinol. 2017 Mar;232(3):411-422. doi: 10.1530/JOE-16-0561. Epub 2016 Dec 20.

  PMID: 27999089 BACKGROUND

• Flint A, Raben A, Blundell JE, Astrup A. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord. 2000 Jan;24(1):38-48. doi: 10.1038/sj.ijo.0801083.

  PMID: 10702749 BACKGROUND

Study Officials

• James Dorling, PhD

  University of Glasgow

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sultan Alenezi, MSc

CONTACT

+44 778 653 0734; a.sultan-kheneisr-w.1@research.gla.ac.uk

James Dorling, PhD

CONTACT

+44 141 201 6696; James.Dorling@glasgow.ac.uk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer

Study Record Dates

• First Submitted: October 11, 2023
• First Posted: October 23, 2023
• Study Start: November 6, 2023
• Primary Completion (Estimated): October 5, 2026
• Study Completion (Estimated): October 5, 2026
• Last Updated: January 7, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will share
• Time Frame: The data will be available when the study is completed. Data will be preserved for 10 years.
• Access Criteria: Data will be shared via the repository deposit (Enlighten). Only signatories of end-user agreements can access and use shared data.

Locations

GB (1)