Effect of Exercise on Appetite in Response to Meals During Energy Restriction

NCT06895837 | Recruiting

• 1 other identifier: 200240250
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

This study's primary aim is to investigate the acute effect of an exercise bout (30 minutes) on appetite and appetite-regulatory hormone responses during energy restriction. The researchers will also test if the exercise bout influences ad libitum energy intake after a period of energy restriction. The researchers will compare three groups (control, severe-energy restriction, and severe-energy restriction with exercise) to see if exercise bout, during energy restriction, affects appetite, appetite-regulatory hormones, and energy intake in healthy men.

Conditions

Healthy

Outcome Measures

Primary Outcomes (4)

• Change in Peptide-YY (PYY)

  The researchers will draw blood samples at different time points during the trial to measure the change in PYY blood levels. Area under the plasma concentration versus time curve (AUC) of PYY will be calculated using the trapezoidal rule.

  At 0 (baseline), 0.5, 1, 1.5, 2, 3, 4, 5, 5.5, 6, 6.5, 7, and 23 hours

• Change in Ghrelin

  The researchers will draw blood samples at different time points during the trial to measure the change in ghrelin blood levels. Area under the plasma concentration versus time curve (AUC) of ghrelin will be calculated using the trapezoidal rule.

  At 0 (baseline), 0.5, 1, 1.5, 2, 3, 4, 5, 5.5, 6, 6.5, 7, and 23 hours

• Change in Glucagon-Like Peptide-1 (GLP-1)

  The researchers will draw blood samples at different time points during the trial to measure the change in GLP-1 blood levels. Area under the plasma concentration versus time curve (AUC) of GLP-1 will be calculated using the trapezoidal rule.

  At 0 (baseline), 0.5, 1, 1.5, 2, 3, 4, 5, 5.5, 6, 6.5, 7, and 23 hours

• Change in subjective appetite sensations

  The researchers will assess the subjective appetite sensations using 100 mm visual analog scales (VAS) to measure appetite sensations (hunger, satiety, fullness, prospective food consumption, and desire to eat). The VAS are 100 mm long, with words anchored at each end expressing the most positive and negative ratings. Scores for each appetite construct range from 0-100.

  At 0 (baseline), 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 5.5, 6, 6.5, 7, 23, 24, and 25 hours

Secondary Outcomes (2)

• Energy Intake

  At 24 hours

• Macro-nutrient Intake

  At 24 hours

Study Arms (3)

Control

NO INTERVENTION

The participants will not perform any exercise and will receive 100% of their estimated energy needs.

Severe-energy restriction

EXPERIMENTAL

The participants will not perform any exercise and will receive 25% of their estimated energy needs.

Other: Severe-energy restriction

Severe-energy restriction with exercise

EXPERIMENTAL

The participants will run on the treadmill for 30 minutes and receive 25% of their estimated energy needs.

Other: Severe-energy restriction with exercise

Interventions

Severe-energy restriction OTHER

The participants will receive only 25% of their estimated energy needs.

Severe-energy restriction

Severe-energy restriction with exercise OTHER

The participants will run on the treadmill for 30 minutes and receive 25% of their estimated energy needs.

Severe-energy restriction with exercise

Eligibility Criteria

• Age: 18 Years - 65 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Males aged 18 years or older.
• Have stable body mass for at least six months (within ±2 kg).

You may not qualify if:

• Females
• People who are younger than 18 or older than 65 years old.
• Following a special diet (e.g. weight loss, vegetarian or vegan, etc.).
• Have food allergies related to the study.
• Have significant contraindications to exercise (e.g., an injury that would inhibit running).
• Smoking.
• Taking any medications.
• Suffering from metabolic health issues, e.g., history of diabetes, cardiovascular disease, or eating disorders.
• Have any mental health conditions.

Sponsors & Collaborators

• University of Glasgow: lead
• Northern Border University: collaborator

Study Sites (1)

New Lister Building, Glasgow Royal Infirmary

Glasgow, United Kingdom

RECRUITING

Related Publications (2)

• Flint A, Raben A, Blundell JE, Astrup A. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord. 2000 Jan;24(1):38-48. doi: 10.1038/sj.ijo.0801083.

  PMID: 10702749 BACKGROUND

• Broom DR, Miyashita M, Wasse LK, Pulsford R, King JA, Thackray AE, Stensel DJ. Acute effect of exercise intensity and duration on acylated ghrelin and hunger in men. J Endocrinol. 2017 Mar;232(3):411-422. doi: 10.1530/JOE-16-0561. Epub 2016 Dec 20.

  PMID: 27999089 BACKGROUND

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• James Dorling, PhD

  University of Glasgow

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sultan Alenezi, MSc

CONTACT

+44 778 653 0734; a.sultan-kheneisr-w.1@research.gla.ac.uk

James Dorling, PhD

CONTACT

+44 141 201 6696; James.Dorling@glasgow.ac.uk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer in Human Nutrition (Medicine)

Study Record Dates

• First Submitted: March 19, 2025
• First Posted: March 26, 2025
• Study Start: July 30, 2025
• Primary Completion (Estimated): April 30, 2028
• Study Completion (Estimated): April 30, 2028
• Last Updated: January 7, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will share
• Time Frame: Data will be preserved for 10 years.

Locations

GB (1)