NCT06084455

Brief Summary

This study investigates the modification of the local-to-global connectivity pattern in response to a session of aerobic exercise. Transcranial magnetic stimulation (TMS) will be applied to elicit electroencephalography (EEG) responses in healthy volunteers. The TMS-evoked potentials (TEPs) will be recorded and serve as a reflection of cortical reactivity and connectivity to TMS.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Oct 2023

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 10, 2023

Completed
5 days until next milestone

Study Start

First participant enrolled

October 15, 2023

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 16, 2023

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 4, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 4, 2025

Completed
Last Updated

February 7, 2025

Status Verified

October 1, 2023

Enrollment Period

1.3 years

First QC Date

October 10, 2023

Last Update Submit

February 4, 2025

Conditions

Transcranial Magnetic StimulationElectroencephalographyAerobic Exercise

Outcome Measures

Primary Outcomes (1)

  • Cortical connectivity

    Global and local mean field amplitude

    Cortical connectivity changes will be investigated before and after 30-min aerobic exercise (1 hour)

Secondary Outcomes (1)

  • Cortical excitability

    Cortical excitability changes will be investigated before and after 30-min aerobic exercise (1 hour)

Study Arms (1)

Aerobic exercise

EXPERIMENTAL

30 minutes of aerobic exercise will be performed by the participants before and after cortical connectivity measurements.

Other: Aerobic exercise

Interventions

Aerobic exerciseOTHER

30 minutes of aerobic exercise on a stationary bike

Aerobic exercise

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Healthy men and women
  • Speak and understand English

You may not qualify if:

  • Drug addiction defined as the use of cannabis, opioids or other drugs
  • Previous neurologic, musculoskeletal or mental illnesses
  • Lack of ability to cooperate
  • History of chronic pain or current acute pain
  • Contraindications to rTMS application (history of epilepsy, metal in the head or jaw etc.).
  • Failure to pass the "TASS questionnaire" (TASS = Transcranial Magnetic Stimulation Adult Safety Screen)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Aalborg University

Gistrup, North Denmark, 9260, Denmark

Location

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Dr

Study Record Dates

First Submitted

October 10, 2023

First Posted

October 16, 2023

Study Start

October 15, 2023

Primary Completion

February 4, 2025

Study Completion

February 4, 2025

Last Updated

February 7, 2025

Record last verified: 2023-10

Locations

DK(1)