NCT07016594

Brief Summary

The purpose of this research was to explore potential differences in acute cardiovascular responses between two conditions: 1) moderate-intensity cycle ergometer exercise; and 2) moderate-intensity cycle ergometer exercise with NMES. Young, healthy, physically active participants were recruited for this study.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jan 2022

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 25, 2022

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2023

Completed
2 years until next milestone

First Submitted

Initial submission to the registry

June 4, 2025

Completed
7 days until next milestone

First Posted

Study publicly available on registry

June 11, 2025

Completed
Last Updated

June 15, 2025

Status Verified

June 1, 2025

Enrollment Period

1.3 years

First QC Date

June 4, 2025

Last Update Submit

June 11, 2025

Conditions

Aerobic Exercise

Outcome Measures

Primary Outcomes (1)

  • Oxygen consumption

    L/min

    20 minutes

Secondary Outcomes (7)

  • Carbon dioxide production

    20 minutes

  • Heart rate

    20 minutes

  • Respiratory exchange ratio

    20 minutes

  • Rating of perceived exertion

    20 minutes

  • Kilocalories utilized

    20 minutes

  • +2 more secondary outcomes

Study Arms (2)

Aerobic exercise alone

ACTIVE COMPARATOR

Participants completed aerobic exercise acutely

Behavioral: Aerobic exercise

Aerobic exercise with neuromuscular electrical stimulation of the leg musculature

EXPERIMENTAL

Participants completed aerobic exercise with neuromuscular electrical stimulation

Behavioral: Aerobic exercise

Interventions

Aerobic exerciseBEHAVIORAL

Aerobic exercise was done with and without neuromuscular electrical stimulation

Aerobic exercise aloneAerobic exercise with neuromuscular electrical stimulation of the leg musculature

Eligibility Criteria

Age18 Years - 30 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • healthy
  • performing aerobic activity greater than or equal to three times per week at any intensity

You may not qualify if:

  • had lower body musculoskeletal injuries recently (within the past 6 months)
  • health conditions that may place risk to the individual such as those with respiratory issues, hypertension, chronic atrial fibrillation, valvular diseases, heart disease; or obstructive cardiomyopathy
  • if taking pharmacological drugs, performance-enhancing drugs, recreational drugs, nutritional supplements, or smoked nicotine

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Active Living Centre/Applied Research Centre

Winnipeg, Manitoba, R3T2N2, Canada

Location

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

June 4, 2025

First Posted

June 11, 2025

Study Start

January 25, 2022

Primary Completion

June 1, 2023

Study Completion

June 1, 2023

Last Updated

June 15, 2025

Record last verified: 2025-06

Locations

CA(1)