NCT06078358

Brief Summary

The purpose of this study is examine the effects of 8 weeks (3 days/week) of resistance exercise training in children 8 to 10 years of age on muscle strength, activation, and lipids of the vastus lateralis.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
32

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Aug 2021

Typical duration for not_applicable

Geographic Reach
1 country

4 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 2, 2021

Completed
2.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 6, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 6, 2023

Completed
29 days until next milestone

First Submitted

Initial submission to the registry

October 5, 2023

Completed
6 days until next milestone

First Posted

Study publicly available on registry

October 11, 2023

Completed
Last Updated

October 13, 2023

Status Verified

October 1, 2023

Enrollment Period

2.1 years

First QC Date

October 5, 2023

Last Update Submit

October 10, 2023

Conditions

Resistance Training

Keywords

exercisemuscle cross-sectional areaintramyocellular lipidsextramyocellular lipidsstrength

Outcome Measures

Primary Outcomes (1)

  • Change in the muscular strength of leg extensors, as measured with isometric strength.

    The score will reflect the strength of the leg extensors. The higher score, reflects greater muscular strength.

    baseline, following the intervention (9 weeks)

Secondary Outcomes (3)

  • Change from baseline in motor unit firing rates during a 60% of maximal voluntary contraction (MVC).

    baseline, following the intervention (9 weeks)

  • Change from baseline in motor unit firing rates during a 60% of maximal voluntary contraction (MVC).

    baseline, following the intervention (9 weeks)

  • Change from baseline in thigh muscle cross-sectional area.

    baseline, following the intervention (9 weeks)

Other Outcomes (6)

  • Change from baseline in the fatty acid saturation levels of the extramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy

    baseline, following the intervention (9 weeks)

  • Change from baseline in the fatty acid saturation levels of the intramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy

    baseline, following the intervention (9 weeks)

  • Change from baseline in motor unit firing rates during a 35% of maximal voluntary contraction (MVC).

    baseline, following the intervention (9 weeks)

  • +3 more other outcomes

Study Arms (2)

Resistance exercise training

EXPERIMENTAL

Participants undergo 8 weeks (3 days/week) of resistance exercise training.

Other: Resistance exercise training

Control

NO INTERVENTION

Participants do not perform 8 weeks of resistance exercise training.

Interventions

Resistance exercise trainingOTHER

Traditional linear periodization resistance training.

Resistance exercise training

Eligibility Criteria

Age8 Years - 10 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • Healthy volunteer males and females ages 8 - 10 years.

You may not qualify if:

  • No history or ongoing neuromuscular diseases, musculoskeletal injuries, or a disease that effects metabolism.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (4)

Hoglund Biomedical Imaging Center

Kansas City, Kansas, 66103, United States

Location

Exercise and Human Performance Laboratory

Overland Park, Kansas, 66213, United States

Location

Metabolic and Body Composition Laboratory

Overland Park, Kansas, 66213, United States

Location

Energy Balance Laboratory

Kansas City, Missouri, 64108, United States

Location

MeSH Terms

Conditions

Motor Activity

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy ModalitiesPhysical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

October 5, 2023

First Posted

October 11, 2023

Study Start

August 2, 2021

Primary Completion

September 6, 2023

Study Completion

September 6, 2023

Last Updated

October 13, 2023

Record last verified: 2023-10

Data Sharing

IPD Sharing
Will share
Shared Documents
ICF

Locations

US(4)