Influence of Resistance Training Experience and Mental Imagery on Corticospinal Excitability and Inhibition

NCT03889548 | Completed

• 1 other identifier: 00000170
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study will utilize transcranial magnetic stimulation (TMS) to examine the effects of mental imagery in resistance-trained versus untrained men and women. In randomized order, each participant will perform a mental imagery task or a control condition as TMS is used to study corticospinal excitability.

Conditions

Resistance Training

Outcome Measures

Primary Outcomes (1)

• Corticospinal Excitability

  Peak-to-peak amplitude of the motor evoked potential of the first dorsal interosseous at 130% of resting motor threshold

  Greater than or equal to 24 hours to 7 days between visits.

Study Arms (2)

Mental Imagery

EXPERIMENTAL

Other: Mental Imagery

Control

NO INTERVENTION

Interventions

Mental Imagery OTHER

Immediately after determination of the resting motor threshold and pre-test measurements, the TMS administrator will leave the room so as to be blinded to the treatment condition of the participant. At this time the participant will be given instructions regarding the mental imagery protocol from a separate investigator who will not be blinded to the condition. During the mental imagery protocol, participants will be instructed to close their eyes and imagine they are maximally contracting the muscles in their forearm and imagine that they are making their wrist flex and that they are pushing maximally against a hand grip in their hand. This will be a kinesthetic imagery task, in which they are urging their muscles to contract maximally.

Mental Imagery

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Over the previous six months, participant has performed at least three resistance training sessions per week or
• Over the previous six months, participant has refrained from resistance training entirely.

You may not qualify if:

• Do not meet the resistance training experience requirements of either group
• Neuromuscular disease (e.g. Parkinson's, MS, ALS)
• Metabolic disease (e.g. diabetes, thyroid disorder, metabolic syndrome)
• Arthritis in the upper limbs (hands, arms, shoulders)
• Trouble using or controlling one's muscles
• History of cancer
• History of stroke
• History of heart attack
• Use of an assistive walking device or other mobility aids
• Physician mandated contraindication to exercise within the last 6 months
• Epilepsy or history of convulsions/seizures
• History of fainting or syncope
• History of head trauma that was diagnosed as concussion or was associated with loss of consciousness
• History of hearing problems or tinnitus
• Cochlear implants

Sponsors & Collaborators

• University of Central Florida: lead

Study Sites (1)

Central Florida Research Park; Partnership 1 Building; UCF Neuromuscular Plasticity Laboratory

Orlando, Florida, 32826, United States

Location

Related Publications (1)

• Parsowith EJ, Stock MS, Girts RM, Beausejour JP, Alberto A, Carr JC, Harmon KK. The Influence of Resistance Training Experience on the Efficacy of Motor Imagery for Acutely Increasing Corticospinal Excitability. Brain Sci. 2023 Nov 25;13(12):1635. doi: 10.3390/brainsci13121635.

  PMID: 38137083 DERIVED

Study Officials

• Matt S Stock, Ph.D.

  School of Kinesiology and Physical Therapy

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: Within-subjects design with mental imagery and control conditions performed in random order

Study Record Dates

• First Submitted: March 22, 2019
• First Posted: March 26, 2019
• Study Start: February 7, 2019
• Primary Completion: January 1, 2023
• Study Completion: January 1, 2023
• Last Updated: February 17, 2023

Record last verified: 2023-02

Locations

US (1)