Periodontal Status in Patients With Chronic Skin Diseases

NCT06073613 | Completed

• 1 other identifier: HoChiMinhCityUMP_FOS
• Study Type: observational
• Target: 146
• Locations: 1 country
• Sites: 1

Brief Summary

Objective: This study aimed to evaluate and compare the periodontal status of chronic skin disease (CSD) patients with healthy controls. Material and method: 109 patients and 37 healthy subjects were included in this study. Parameters evaluated included bleeding on probing index (BOP), periodontal pocket depths (PPD), clinical attachment level (CAL), simplified debris index (DI), simplified calculus index (CI), and the presence of oral lesions. Clinical parameters were measured and compared in the two groups. The significant level was set at 0.05.

Conditions

Periodontal Diseases; Psoriasis; Atopic Dermatitis; Autoimmune Bullous Dermatosis; Systemic Lupus Erythematosus

Keywords

chronic skin disease; periodontal status; oral lesions

Outcome Measures

Primary Outcomes (6)

• Full mouth bleeding on probing scores (BOP)

  BOP was recorded and considered positive when bleeding occurred within 20 seconds after the probe was removed after application with light pressure. A bleeding percentage was calculated for each patient by dividing the total number of positive bleeding sites by the total number of probed sites

  baseline

• Pocket probing depth (PPD)

  PPD was measured from the gingival margin to the base of the gingival sulcus/ periodontal pocket with the aid of a University of North Carolina (UNC) 15-mm periodontal probe

  baseline

• Clinical attachment level (CAL)

  was measured from the cemento-enamel junction (CEJ) to the base of the gingival sulcus/ periodontal pocket with the aid of a UNC periodontal probe. The CAL was considered zero if the attachment was at the level of the CEJ. If the free gingival margin was coronal to the CEJ, the CAL was determined by measuring the PPD and subtracting the distance from the CEJ to the free gingival margin. When the free gingival margin was apical to the CEJ, the CAL was determined by measuring the distance from the CEJ to the free gingival margin and adding it to the PPD

  Baseline

• debris index (DI)

  DI were evaluated pertaining to the Simplified Oral Hygiene Index (OHI-S) as suggested by Green and Vermillion (1964)

  Baseline

• calculus index (CI)

  CI were evaluated pertaining to the Simplified Oral Hygiene Index (OHI-S) as suggested by Green and Vermillion (1964)

  Baseline

• the number of oral lesions

  Probed sites were classified into three different categories of PPD and CAL (≤ 3 mm, 4-5 mm, \> 6mm)

  Baseline

Study Arms (2)

control group

healthy individuals, aged 18 years or older and free of chronic skin diseases, willing to participate in the study

Diagnostic Test: oral health status

Patients with CSDs

Patients with CSDs (psoriasis, atopic dermatitis, autoimmune bullous diseases, or systemic lupus erythematosus,…) were diagnosed by the dermatologists with over 5 years of experience and supportive laboratory tests, aged 18 years or older, and willing to participate in the study

Diagnostic Test: oral health status

Interventions

oral health status DIAGNOSTIC_TEST

* CSDs medical records: Information related to epidemiological characteristics and chronic inflammatory skin conditions (psoriasis, atopic dermatitis, autoimmune bullous diseases, or systemic lupus erythematosus,…) were recorded from medical records: * Pemphigus * Mixed connective tissue disease * Atopic dermatitis * Psoriasis * Erythroderma * oral health status: oral clinical parameters were evaluated: * Full mouth bleeding on probing scores * Pocket probing depth * Clinical attachment level * debris index * calculus index * the number of oral lesions

Also known as: CSDs medical records

Patients with CSDs; control group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

A prospective case-control study was conducted at Ho Chi Minh City Hospital of Dermato-Venereology in February 2023 to assess the periodontal status of patients with CSDs. The study included 109 patients with CSDs, including psoriasis, atopic dermatitis, lupus, and common autoimmune bullous skin diseases, and 37 healthy controls.

You may qualify if:

• Patient CSDs:
• were diagnosed in CSDs (psoriasis, atopic dermatitis, autoimmune bullous diseases, or systemic lupus erythematosus...) by the dermatologists with over 5 years of experience and supportive laboratory tests
• aged 18 years or older
• willing to participate in the study
• Control group:
• aged 18 years or older
• free of chronic skin diseases

You may not qualify if:

• Toothless
• Limited mouth opening

Sponsors & Collaborators

• University of Medicine and Pharmacy at Ho Chi Minh City: lead

Study Sites (1)

University of Medicine and Pharmacy at Ho Chi Minh city

Ho Chi Minh City, 70000, Vietnam

Location

Related Publications (14)

• Arduino PG, Farci V, D'Aiuto F, Carcieri P, Carbone M, Tanteri C, Gardino N, Gandolfo S, Carrozzo M, Broccoletti R. Periodontal status in oral mucous membrane pemphigoid: initial results of a case-control study. Oral Dis. 2011 Jan;17(1):90-4. doi: 10.1111/j.1601-0825.2010.01709.x.

  PMID: 20659265 BACKGROUND

• Lo Russo L, Gallo C, Pellegrino G, Lo Muzio L, Pizzo G, Campisi G, Di Fede O. Periodontal clinical and microbiological data in desquamative gingivitis patients. Clin Oral Investig. 2014 Apr;18(3):917-25. doi: 10.1007/s00784-013-1038-8. Epub 2013 Jul 31.

  PMID: 23900791 BACKGROUND

• Lo Russo L, Guiglia R, Pizzo G, Fierro G, Ciavarella D, Lo Muzio L, Campisi G. Effect of desquamative gingivitis on periodontal status: a pilot study. Oral Dis. 2010 Jan;16(1):102-7. doi: 10.1111/j.1601-0825.2009.01617.x. Epub 2009 Sep 4.

  PMID: 19735453 BACKGROUND

• Ramon-Fluixa C, Bagan-Sebastian J, Milian-Masanet M, Scully C. Periodontal status in patients with oral lichen planus: a study of 90 cases. Oral Dis. 1999 Oct;5(4):303-6. doi: 10.1111/j.1601-0825.1999.tb00094.x.

  PMID: 10561718 BACKGROUND

• Schellinck AE, Rees TD, Plemons JM, Kessler HP, Rivera-Hidalgo F, Solomon ES. A comparison of the periodontal status in patients with mucous membrane pemphigoid: a 5-year follow-up. J Periodontol. 2009 Nov;80(11):1765-73. doi: 10.1902/jop.2009.090244.

  PMID: 19905946 BACKGROUND

• Thorat MS, Raju A, Pradeep AR. Pemphigus vulgaris: effects on periodontal health. J Oral Sci. 2010 Sep;52(3):449-54. doi: 10.2334/josnusd.52.449.

  PMID: 20881339 BACKGROUND

• Tricamo MB, Rees TD, Hallmon WW, Wright JM, Cueva MA, Plemons JM. Periodontal status in patients with gingival mucous membrane pemphigoid. J Periodontol. 2006 Mar;77(3):398-405. doi: 10.1902/jop.2006.050113.

  PMID: 16512754 BACKGROUND

• Jascholt I, Lai O, Zillikens D, Kasperkiewicz M. Periodontitis in oral pemphigus and pemphigoid: A systematic review of published studies. J Am Acad Dermatol. 2017 May;76(5):975-978.e3. doi: 10.1016/j.jaad.2016.10.028. Epub 2016 Dec 28.

  PMID: 28038889 BACKGROUND

• Macklis P, Adams K, Kaffenberger J, Kumar P, Krispinsky A, Kaffenberger B. The Association Between Oral Health and Skin Disease. J Clin Aesthet Dermatol. 2020 Jun;13(6):48-53. Epub 2020 Jun 1.

  PMID: 32884621 BACKGROUND

• Rai NP, Kumar P, Mustafa SM, Divakar DD, Kheraif AA, Ramakrishnaiah R, Vellapally S, Dalati MH, Parine NR, Anil S. Relation Between Periodontal Status and Pre-Cancerous Condition (Oral Lichen Planus): A Pilot Study. Adv Clin Exp Med. 2016 Jul-Aug;25(4):763-6. doi: 10.17219/acem/59014.

  PMID: 27629852 BACKGROUND

• Listgarten MA. Pathogenesis of periodontitis. J Clin Periodontol. 1986 May;13(5):418-30. doi: 10.1111/j.1600-051x.1986.tb01485.x.

  PMID: 3522650 BACKGROUND

• Offenbacher S, Heasman PA, Collins JG. Modulation of Host PGE2 Secretion as a Determinant of Periodontal Disease Expression. J Periodontol. 1993 May;64 Suppl 5S:432-444. doi: 10.1902/jop.1993.64.5s.432.

  PMID: 29539680 BACKGROUND

• GREENE JC, VERMILLION JR. THE SIMPLIFIED ORAL HYGIENE INDEX. J Am Dent Assoc. 1964 Jan;68:7-13. doi: 10.14219/jada.archive.1964.0034. No abstract available.

  PMID: 14076341 BACKGROUND

• Akman A, Kacaroglu H, Yilmaz E, Alpsoy E. Periodontal status in patients with pemphigus vulgaris. Oral Dis. 2008 Oct;14(7):640-3. doi: 10.1111/j.1601-0825.2008.01445.x.

  PMID: 18627505 RESULT

MeSH Terms

Conditions

Periodontal Diseases; Psoriasis; Dermatitis, Atopic; Lupus Erythematosus, Systemic

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Skin Diseases, Papulosquamous; Skin Diseases; Skin and Connective Tissue Diseases; Skin Diseases, Genetic; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Dermatitis; Skin Diseases, Eczematous; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases; Connective Tissue Diseases; Autoimmune Diseases

Study Officials

• Hao Trong Nguyen, PhD

  Ho Chi Minh City Hospital of Dermato-Venereology, Ho Chi Minh City, Vietnam

  STUDY DIRECTOR

• Thuy Thu Nguyen, PhD

  University of Medicine and Pharmacy at Ho Chi Minh City

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Inverstigator

Study Record Dates

• First Submitted: September 26, 2023
• First Posted: October 10, 2023
• Study Start: January 20, 2023
• Primary Completion: February 28, 2023
• Study Completion: April 28, 2023
• Last Updated: October 10, 2023

Record last verified: 2023-10

Locations

VN (1)