Mechanisms of Exercise-Induced Hypoalgesia

NCT06050889 | Completed

• 1 other identifier: 6
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Exercise-Induced Hypoalgesia (EIH) is a lessening of pain sensitivity in response to an acute bout of exercise. Limited research has examined the effects of expectations on EIH during a dynamic resistance training during different intensities. Therefore, the purpose of this study is to examine the effects of positive and negative expectations on EIH.

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

• Pressure Pain Threshold

  Pressure Pain Threshold will be applied with a digital algometer before and after the exercise intervention.

  Change from baseline immediately after exercise

Study Arms (2)

High Intensity Exercise

EXPERIMENTAL

Participants will complete an upper body resistance exercise until they report a high fatigue level.

Other: Positive Expectations Instructional Set; Other: Negative Expectations Instructional Set

Low Intensity Exercise

EXPERIMENTAL

Participants will complete an upper body resistance exercise until they report a low fatigue level.

Other: Positive Expectations Instructional Set; Other: Negative Expectations Instructional Set

Interventions

Positive Expectations Instructional Set OTHER

Participants randomly assigned to this instructional set will be told, "You will be completing an intervention known to be effective for some people with shoulder pain. We expect this will make you less sensitive to the pressure applied to your shoulder and thigh and you will require more pressure than what was previously necessary to experience pain."

High Intensity Exercise; Low Intensity Exercise

Negative Expectations Instructional Set OTHER

Participants randomly assigned to this instructional set will be told, "You will be completing an intervention which is not effective for some people with shoulder pain. We expect this will make you more sensitive to the pressure applied to your shoulder and thigh and you will require less pressure than what was previously necessary to experience pain."

High Intensity Exercise; Low Intensity Exercise

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Pain Free

You may not qualify if:

• Non-English speaking
• Regular use of prescription pain medications
• Current or history of chronic pain condition
• Currently taking blood-thinning medication
• Any blood clotting disorder, such as hemophilia
• Systemic medical condition known to affect sensation, such as uncontrolled diabetes or neurological conditions
• Not physically ready to exercise without a medical exam as indicated by the Physical Activity Readiness Questionnaire Plus (PAR-Q+)
• Not have had Surgery, injury, or fracture within the past 6 months

Sponsors & Collaborators

• University of Central Florida: lead

Study Sites (1)

University of Central Florida

Orlando, Florida, 32765, United States

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: September 15, 2023
• First Posted: September 22, 2023
• Study Start: November 14, 2023
• Primary Completion: April 19, 2024
• Study Completion: April 19, 2024
• Last Updated: April 22, 2024

Record last verified: 2024-04

Locations

US (1)