NCT06048406

Brief Summary

The goal of this cluster randomized controlled trial is to evaluate the effect of health education interventions on influenza vaccination rates and health literacy in primary school students in the city of Dongguan in China. Individuals aged 7 to 12 years who are in grades 4-5 in primary schools in Dongguan will be enrolled. 20 primary schools will be randomly selected, with half designated as intervention group schools and the remaining half as control group schools. The intervention group will receive a monthly health education intervention focused on influenza vaccination for 5 months, while the control group will continue with their routine school health education for 5 months. Researchers will compare the differences in influenza vaccination rates and influenza vaccination health literacy levels between the intervention and control groups after 5 months to see if health education can promote influenza vaccination health literacy among primary school students.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
3,036

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Sep 2023

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 8, 2023

Completed
3 days until next milestone

Study Start

First participant enrolled

September 11, 2023

Completed
10 days until next milestone

First Posted

Study publicly available on registry

September 21, 2023

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2024

Completed
Last Updated

February 21, 2024

Status Verified

February 1, 2024

Enrollment Period

10 months

First QC Date

September 8, 2023

Last Update Submit

February 19, 2024

Conditions

Keywords

health educationhealth literacyschoolsChina

Outcome Measures

Primary Outcomes (1)

  • influenza vaccination rate

    he influenza vaccination rate will be calculated as the number of vaccinated individuals divided by the total number of individuals, multiplied by 100%.

    Within 20 weeks from enrollment

Secondary Outcomes (4)

  • influenza vaccination health literacy level

    Within 20 weeks from enrollment

  • influenza incidence

    Within 20 weeks from enrollment

  • influenza vaccine protection rate

    Within 20 weeks from enrollment

  • influenza-like illness incidence

    Within 20 weeks from enrollment

Study Arms (2)

Intervention

EXPERIMENTAL

The intervention group will receive a monthly health education intervention focused on influenza vaccination literacy for 5 months.

Combination Product: Health education

Control

NO INTERVENTION

The control group will continue with their routine school health education for 5 months.

Interventions

Health educationCOMBINATION_PRODUCT

The intervention group will receive a health education intervention focused on influenza vaccination literacy, while the control group will continue with their standard school health education without any additional intervention. An influenza vaccination health education including topics such as the importance of influenza vaccination, benefits of vaccination, and vaccination methods, will be developed and reviewed by an expert group. The package for the intervention group will include educational activities, distribution of promotional materials, vaccination services, and distribution of vaccination souvenirs.

Intervention

Eligibility Criteria

Age7 Years - 12 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • Primary school students within the age range of 7-12 years.
  • Students and their parents who voluntarily agree to participate in the study and provide signed informed consent.
  • Permanent residents of Dongguan City who are expected to complete the project without transferring schools during the study period.

You may not qualify if:

  • Individuals with contraindications to influenza vaccination, who have recently received an influenza vaccination, diagnosed with influenza or confirmed as influenza-like cases at the commencement of the study.
  • Unwilling to participate in the project.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Dongguang Center for Disease Control and Prevention

Dongzhoucun, Guangdong, 510000, China

RECRUITING

Related Publications (2)

  • Chen J, Xie W, Huang X, Huang A, Lu T, Zhang R, Xiao J, He S, Wang J, Xu L. Impact of multifaceted health education on influenza vaccination health literacy in primary school students: a cluster randomized controlled trial. BMC Med. 2025 Jun 4;23(1):333. doi: 10.1186/s12916-025-04156-1.

  • Xie W, Xiao J, Chen J, Huang H, Huang X, He S, Xu L. Impact of health education on promoting influenza vaccination health literacy in primary school students: a cluster randomised controlled trial protocol. BMJ Open. 2024 Apr 12;14(4):e080115. doi: 10.1136/bmjopen-2023-080115.

MeSH Terms

Conditions

InfectionsInfluenza, HumanHealth Education

Condition Hierarchy (Ancestors)

Respiratory Tract InfectionsOrthomyxoviridae InfectionsRNA Virus InfectionsVirus DiseasesRespiratory Tract DiseasesAdherence InterventionsMedication AdherencePatient CompliancePatient Acceptance of Health CareTreatment Adherence and ComplianceHealth BehaviorBehavior

Study Officials

  • Lin Xu, PhD

    Sun Yat-sen University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Chen Jingyi, Master

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Masking Details
Outcomes Assessor will not know the intervention status of the participants.
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

September 8, 2023

First Posted

September 21, 2023

Study Start

September 11, 2023

Primary Completion

June 30, 2024

Study Completion

June 30, 2024

Last Updated

February 21, 2024

Record last verified: 2024-02

Data Sharing

IPD Sharing
Will not share

Locations