Eccentric Resistance Training Among Individuals With Chronic Heart Failure

NCT06032780 | Recruiting DMC

• 1 other identifier: ISB/REC/PhD/01199 Iqbal Tariq
• Study Type: interventional
• Target: 84
• Locations: 1 country
• Sites: 2

Brief Summary

To determine the effects of eccentric resistive training on ventricle functions and aerobic capacity as compared to a resistance and aerobic training among Heart failure (HF)

Conditions

Heart Failure

Outcome Measures

Primary Outcomes (2)

• Ventricle Functions

  Changes from the baseline will be measured. Doppler resting echocardiography will be performed to measure ventricle functions. Standard views, including the parasternal long-axis, short-axis at the papillary muscle level, and apical 4- and 2-chamber views will be recorded. Left ventricular ejection fraction (LVEF) and end systolic and end-diastolic diameters (LVESD and LVEDD) will be measured using formula (Tiecholz formula i-e spherical volume of the heart multiplied by a correction factor). Any structural changes will also be recorded.

  12 week

• Aerobic Capacity

  Changes will be measured at baseline, 4th week, 8th week and 12th week. The 6-min walk test provides an indirect measure of cardiovascular functional/aerobic capacity. Six Minute Walk test (6MWT) will be used to assess the functional capacity of the individuals with HF. The subjects will be instructed to walk for 6 minutes at a given time along a 30-m line at an interval of 1.5 m in an outdoor corridor, and the distance walked will be recorded in meters. The participants will be encouraged to continue walking as fast as possible. Then a generalized equation will be used to predict peak VO2 from 6 minute walk distance (6MWD) with the help of formula. Mean Peak VO2 (ml/kg/Mean) = 4.948 + 0.023 \*Mean 6MWD (meters)

  12 week

Secondary Outcomes (9)

• Quality of life (Minnesota Living with Heart Failure Questionnaire)

  12 week

• Strength

  12 week

• Maximal strength of respiratory muscles

  12 week

• Forced Expiratory Volume in 1 second (FEV1)

  12 week

• Forced vital Capacity (FVC)

  12 week

Other Outcomes (9)

• Oxygen Saturation (SpO2)

  12 week

• Change in heart rate variability (HRV)

  12 week

• Modified Borg Dyspnoea Scale

  12 week

Study Arms (3)

Eccentric Resistive Training + Aerobic training Group

EXPERIMENTAL

Other: Eccentric Resistive Training + Aerobic training Group

Resistance Training + Aerobic training Group

ACTIVE COMPARATOR

Other: Resistance Training + Aerobic training Group

Aerobic training Group

ACTIVE COMPARATOR

Other: Aerobic training Group

Interventions

Eccentric Resistive Training + Aerobic training Group OTHER

Eccentric Resistive training includes upper limb (biceps and triceps) and lower limb large muscle training (quadriceps and hamstrings) 2 sets of 12 repetitions (reps) for each group of muscles in lengthened position for eccentric training in approx. 20 minutes (min). Intensity will be based on 1 repetition maximum (1RM) starting from 20% of (1RM) and its intensity in percentage will be progress by 10% after every two weeks. Stair descending training and squatting position and eccentric hamstring curls with weights at ankle for lower limb eccentric training progressive as per tolerance in response to modified Borg scale (with cut off of showing dyspnea of 4 somewhat hard) and Numeric Pain rating scale (with cut off of showing 7 on scale, crossing moderate pain) . (approx. 20 min). \+ Aerobic training as a control will be given to this group as well for approximately 30 minutes per session.

Eccentric Resistive Training + Aerobic training Group

Resistance Training + Aerobic training Group OTHER

Resistive training (concentric) includes Upper limb (biceps and triceps) and lower limb large muscle training (quadriceps and hamstrings), 2 sets of 12 reps for each group of muscles in approx. 30 min. Intensity will be based on 1 repetition maximum (1RM) starting from 20% of (1RM) and its intensity in percentage will be progress by 10% after every two weeks. Stair climbing training and quadriceps training + standing hamstring curls with weight at ankle for lower limb concentric training progressive as per tolerance in response to modified Borg scale (with cut off of showing dyspnea of 4 somewhat hard) and Numeric Pain rating scale (with cut off of showing 7 on scale, crossing moderate pain) \+ Aerobic training as a control will be given to this group as well for approximately 30 minutes per session.

Resistance Training + Aerobic training Group

Aerobic training Group OTHER

Aerobic training as a control will be given to this group as well for approximately 60 minutes per session. Aerobic training exercise will be completed via a ergometer/stationary cycle; type will be continuous aerobic exercise and intensity of 60% of max HR (or peak VO2) in HF individuals.

Aerobic training Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of Chronic HF and currently stable with optimal medical therapy
• Chronic Heart failure with ejection fraction \> 30 %
• Patient able to safely perform lower limb exercise will be check by six- minute walk test (6 MWT)

You may not qualify if:

• Those Heart failure patient whose are in acute phase or planed for any immediate medical intervention
• Already participating in cardiac rehabilitation
• New York Heart Association (NYHA) Classification of HF class IV HF symptoms
• Co-existent other disease such as asthma/ COPD/interstitial lung disease.
• Symptomatic Second degree or third degree heart block.
• ECG with uncontrolled ventricular arrhythmia
• Limited Exercise ability due to neurologic or orthopedic impairments of the legs (will cross-check with 6 MWT)

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (2)

Pakistan Railway Hospital

Rawalpindi, Punjab Province, 46000, Pakistan

SUSPENDED

Rawalpindi Institute of Cardiology

Rawalpindi, Punjab Province, 46000, Pakistan

RECRUITING

MeSH Terms

Conditions

Heart Failure

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Muhammad Iqbal Tariq, PhD*

  Riphah International University

  PRINCIPAL INVESTIGATOR

• Arshad Nawaz Malik, PhD

  Riphah International University

  STUDY CHAIR

• Shane Patman, PhD

  University of Notre Dame Australia

  STUDY CHAIR

Central Study Contacts

Muhammad Iqbal Tariq, PhD*

CONTACT

+923338236752; iqbal.tariq@riphah.edu.pk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: CARE PROVIDER, OUTCOMES ASSESSOR
• Masking Details: Group allocation will be kept blinded to the assessor and to the treatment provider (trained physical therapist).
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 5, 2023
• First Posted: September 13, 2023
• Study Start: September 20, 2023
• Primary Completion: May 1, 2026
• Study Completion: May 1, 2026
• Last Updated: November 19, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

PA (2)