The Cartilage and Muscle Thickness on Knee Pain in Patients With Rheumatoid Arthritis

NCT05999266 | Completed

• 1 other identifier: 15082023
• Study Type: observational
• Target: 130
• Locations: 1 country
• Sites: 1

Brief Summary

The knee pain status of the patients who are followed in the rheumatology special branch of the Physical Medicine and Rehabilitation Outpatient Clinic and who meet the inclusion criteria will be questioned. In patients with or without knee pain, the cartilage thickness measurement of the knee joint will be measured from 3 points by ultrasound. At the same time, Quadriceps and Hamstring muscle thickness measurements of the patients will be made from the midpoints where the muscle thickness is the highest. The physician who performed the ultrasonographic measurements of the knee pain status of the patients does not know.

Conditions

Rheumatoid Arthritis; Knee Pain Chronic; Muscle Loss; Cartilage Degeneration

Outcome Measures

Primary Outcomes (2)

• Ultrasonographic Cartilage Thickness Measurement

  Tibial cartilage thickness will be visualized by ultrasound with the knee held in 30 degrees of flexion, and 3 measurements will be taken from the medial, lateral and midline.

  through study completion, an average of 1 month

• Ultrasonographic Muscle Measurement Thickness Measurement

  The quadriceps muscle thickness will be measured by determining the midpoint between the SIAS and the patella while the patient is lying in the supine position. Hamstring muscle thickness will be measured at the intersection of a line drawn at 60% distal between the greater trochanter and the outer femoral condyle, and at the midline of the popliteal fossa, with the patient lying on the prone. These 2 measurements will be proportional to each other.

  through study completion, an average of 1 month

Study Arms (2)

Rheumatoid Arthritis Patients with Knee Pain

In patients with knee pain, the cartilage thickness measurement of the knee joint will be measured from 3 points by ultrasound. At the same time, Quadriceps and Hamstring muscle thickness measurements of the patients will be made from the midpoints where the muscle thickness is the highest.

Diagnostic Test: Ultrasonographic Measurements

Rheumatoid Arthritis Patients without Knee Pain

In patients without knee pain, the cartilage thickness measurement of the knee joint will be measured from 3 points by ultrasound. At the same time, Quadriceps and Hamstring muscle thickness measurements of the patients will be made from the midpoints where the muscle thickness is the highest.

Diagnostic Test: Ultrasonographic Measurements

Interventions

Ultrasonographic Measurements DIAGNOSTIC_TEST

In patients with or without knee pain, the cartilage thickness measurement of the knee joint will be measured from 3 points by ultrasound. At the same time, Quadriceps and Hamstring muscle thickness measurements of the patients will be made from the midpoints where the muscle thickness is the highest.

Rheumatoid Arthritis Patients with Knee Pain; Rheumatoid Arthritis Patients without Knee Pain

Eligibility Criteria

• Age: 30 Years - 50 Years
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients with Rheumatoid Arthritis

You may qualify if:

• Rheumatoid Arthritis \> Diagnosed for 1 year
• Female gender
• The patient has been in remission or low disease activity for at least 3 months
• Be able to ambulatory
• No significant deformity in the lower extremity joints

You may not qualify if:

• Patient with active arthritis or high disease activity
• \- Significant deformity of the lower extremity joints and inability to ambulate
• Pregnant patient
• \- Presence of malignancy
• \- Patient with a severe psychiatric disorder and difficulty in cooperation
• \- Presence of cardiovascular and pulmonary comorbidities that will prevent exercise
• Male gender

Sponsors & Collaborators

• Sisli Hamidiye Etfal Training and Research Hospital: lead

Study Sites (1)

University of Health Sciences, Şişli Hamidiye Etfal Training and Research Hospital

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Arthritis, Rheumatoid; Muscular Atrophy

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Week
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor

Study Record Dates

• First Submitted: August 13, 2023
• First Posted: August 21, 2023
• Study Start: September 28, 2023
• Primary Completion: November 10, 2023
• Study Completion: November 12, 2023
• Last Updated: November 21, 2023

Record last verified: 2023-11

Locations

TU (1)