NCT07194031

Brief Summary

The goal of this randomized research study is to investigate the acute effects of ankle exercises on improving knee proprioception and pain in individuals with knee pain, aged 18-70, who receive intervention-based ankle and knee exercises to treat their knee pain. The main question it aims to answer is: • Does ankle exercise affect knee joint proprioception and pain in individuals with knee pain? Researchers will compare ankle exercise (the intervention) with knee exercise (as part of their regular medical care for knee pain) to determine if ankle exercise is effective in improving knee joint proprioception and reducing pain. Participants will be asked to do exercises and to let the researchers take their measurements.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
114

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jan 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 6, 2025

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 30, 2025

Completed
21 days until next milestone

Study Completion

Last participant's last visit for all outcomes

June 20, 2025

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

September 10, 2025

Completed
16 days until next milestone

First Posted

Study publicly available on registry

September 26, 2025

Completed
Last Updated

September 26, 2025

Status Verified

September 1, 2025

Enrollment Period

5 months

First QC Date

September 10, 2025

Last Update Submit

September 25, 2025

Conditions

Keywords

AnkleExerciseKneePainProprioception

Outcome Measures

Primary Outcomes (1)

  • Knee proprioception

    Knee flexion- extension position

    4 weeks

Secondary Outcomes (1)

  • Knee pain

    4 weeks

Study Arms (2)

Knee exercise

ACTIVE COMPARATOR

Knee flexion-extension

Other: Knee Exercise

Ankle exercise

EXPERIMENTAL

Ankle plantar flexion with body weight

Other: Ankle Exercise

Interventions

In the literature, studies have evaluated ankle proprioception following interventions applied to the knee. However, no studies report the effects of ankle exercises on knee proprioception

Also known as: Plantar flexion
Ankle exercise

The literature emphasizes that long-term and multidirectional exercise programs provide proprioceptive improvements

Also known as: Knee flexion-extension
Knee exercise

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • The participants who have a VAS pain score \>5,
  • The participants who have experienced knee pain for the last six months or longer,
  • The participants who volunteered to participate in the study

You may not qualify if:

  • Individuals who had undergone knee and ankle surgery within the last year
  • Individuals who have a VAS pain score below 5
  • Individuals who are experiencing ROM limitations in the knee or ankle
  • Individuals who have a neurological pathology in the lower extremity

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Gaziantep Islam Science and Technology University

Gaziantep, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Motor ActivityPain

Condition Hierarchy (Ancestors)

BehaviorNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Ankle- Knee Exercises
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associated Proffessor

Study Record Dates

First Submitted

September 10, 2025

First Posted

September 26, 2025

Study Start

January 6, 2025

Primary Completion

May 30, 2025

Study Completion

June 20, 2025

Last Updated

September 26, 2025

Record last verified: 2025-09

Data Sharing

IPD Sharing
Will not share

Locations