Characterization of Dynamic Stability in Normal Pressure Hydrocephalus and Parkinson's Disease

NCT05998473 | Unknown

• 1 other identifier: 2023-A01762-43
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to characterize dynamic stability disorders in two conditions mainly affecting the elderly and with similar walking deficits: hydrocephalus at normal pressure and Parkinson's disease, to provide the most relevant monitoring criteria in usual care.

Conditions

Hydrocephalus; Parkinson Disease; Walking, Difficulty; Movement Disorders; Gait Ataxia; Diagnoses Disease

Outcome Measures

Primary Outcomes (1)

• Coefficient of variation in step length

  Coefficient of variation in step length during 8-meter comfortable walking test

  30 seconds

Study Arms (2)

Normal pressure hydrocephalus

Patients with a diagnosis of normal pressure hydrocephalus and who performed a gait analysis in laboratories

Diagnostic Test: Dynamic stability measurement

Parkinson's disease

Patients with a diagnosis of Parkinson's disease and who performed a gait analysis in laboratories

Diagnostic Test: Dynamic stability measurement

Interventions

Dynamic stability measurement DIAGNOSTIC_TEST

The subject is asked to walk 8 meters 3 times: at free speed, at fast speed, and with large steps.

Normal pressure hydrocephalus; Parkinson's disease

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with normal pressure hydrocephalus or Parkinson's disease.

You may qualify if:

• Age \>18 years
• Patient who performed a walking test in the Laboratory Analysis and Restoration of Movement
• Diagnosis of normal pressure hydrocephalus or Parkinson's disease

You may not qualify if:

• Levodopa drugs administrated during a delay of 12 hours before walking test
• Presence of an other neurologic disease or of any disease associated with motor disorders in lower limb.

Sponsors & Collaborators

• Henri Mondor University Hospital: lead

Study Sites (1)

Laboratoire Analyse et Restauration du Mouvement

Créteil, France

Location

MeSH Terms

Conditions

Hydrocephalus; Parkinson Disease; Mobility Limitation; Movement Disorders; Gait Ataxia

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Parkinsonian Disorders; Basal Ganglia Diseases; Synucleinopathies; Neurodegenerative Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Ataxia; Dyskinesias; Neurologic Manifestations; Gait Disorders, Neurologic

Study Officials

• Emilie Hutin

  Henri Mondor University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Co-director of laboratory

Study Record Dates

• First Submitted: August 7, 2023
• First Posted: August 21, 2023
• Study Start: June 1, 2023
• Primary Completion: September 30, 2023
• Study Completion: December 31, 2023
• Last Updated: August 21, 2023

Record last verified: 2023-08

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)