Detecting the Rest Tremor Associated With Parkinson's Disease Using Analysis of the Muscle Contractions Rhythmicity

NCT05998486 | Unknown

• 1 other identifier: ARM-Tremor
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Resting tremors associated with Parkinson's disease (PD) remains difficult to quantify and track during disease progression. This study propose to explore the rhythmicity of distal muscle contractions in the upper limb to characterize resting tremor and discriminate it from cerebellar tremor (CT) based on the frequency spectrum of the EMG signal.

Conditions

Parkinson; Cerebellar Tumor; Rest Tremor; Diagnoses Disease; Movement; Abnormal, Involuntary

Outcome Measures

Primary Outcomes (1)

• rhythmicity index

  The rhythmicity index (RI) is calculated from the ratio of the area of the maximum power peak to the total area of the spectrum between 1.5-12Hz.

  10 seconds

Study Arms (2)

Tremor of rest

Patient with a diagnosis of Parkinson's disease and who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators analysis in Laboratories

Diagnostic Test: EMG in wrist flexor-pronators and extensor-supinators

Cerebellar tremor

Patient with a diagnosis of cerebellar tremor and who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators analysis in Laboratories

Diagnostic Test: EMG in wrist flexor-pronators and extensor-supinators

Interventions

EMG in wrist flexor-pronators and extensor-supinators DIAGNOSTIC_TEST

The subject is asked to perform a series of tasks: resting posture, symmetrical posture arms forward, unilateral distal movement. Each task lasts 10 seconds.

Cerebellar tremor; Tremor of rest

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with Parkinson's disease or cerebellar tremor diagnosis.

You may qualify if:

• patient who performed surface EMG recordings of wrist flexor-pronators and extensor-supinators in Laboratories;
• diagnosis of Parkinson's disease or cerebellar tremor.

You may not qualify if:

• Botulinium toxin injection in upper limb during a delay of 3 months before surface EMG recordings;
• Levodopa drugs administrated during a delay of 12 hours before surface EMG recordings;
• Tremor-favour drugs administrated during a delay of 30 days before surface EMG recordings;
• Presence of an other neurologic disease or of any disease associated with motor disorders in upper limb.

Sponsors & Collaborators

• Henri Mondor University Hospital: lead

Study Sites (1)

Laboratoire Analyse et Restauration du Mouvement

Créteil, France

RECRUITING

MeSH Terms

Conditions

Cerebellar Neoplasms; Tremor; Antisocial Personality Disorder

Interventions

Electromyography

Condition Hierarchy (Ancestors)

Infratentorial Neoplasms; Brain Neoplasms; Central Nervous System Neoplasms; Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Cerebellar Diseases; Dyskinesias; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Personality Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Electrodiagnosis; Diagnostic Techniques and Procedures; Diagnosis; Myography

Study Officials

• Emilie Hutin

  Henri Mondor University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Emilie Hutin, PhD

CONTACT

+33149812549; emilie.hutin@aphp.fr

Emilie Hutin

CONTACT

emilie.hutin@aphp.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Co-director of laboratory

Study Record Dates

• First Submitted: August 7, 2023
• First Posted: August 21, 2023
• Study Start: April 3, 2023
• Primary Completion: September 30, 2023
• Study Completion: December 31, 2023
• Last Updated: August 21, 2023

Record last verified: 2023-08

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)