High Intensity Resistance Training and Possible Sarcopenia

NCT05985616 | Completed

• 1 other identifier: REC01549 Shanza Nisar
• Study Type: interventional
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

Studies conducted so far added the dietary supplements along with resistance training as an intervention, we could not determine whether the observed effects of the intervention were due to the training program and/or dietary supplements.

Conditions

Sarcopenia

Outcome Measures

Primary Outcomes (2)

• Hand Dynamometer

  it used to measure the hand grip strength. the test-retest reliability is 0.91 and 0.95 with excellent reliability. The assessment will be made at baseline, week 8 and 16

  16 weeks

• Short performance physical battery

  an objective assessment tool for evaluating lower extremity functioning in older persons. the test-retest reliability is 0.87. It was used to measure at baseline, week 8 and 16

  16 Week

Secondary Outcomes (1)

• FRAIL

  16 week

Study Arms (2)

Group A

EXPERIMENTAL

High intensity (80-85% of 1RM) will be administered at alternative days for 16 weeks. The exercise will have three phases; Phase I consists of 2-3 sets of 8-15 repetitions, Phase II will follow the single set approach and Phase III will have the Superset approach. The following activities will be incorporated via resistance training: latissimus front pulleys, rowing, back extension, inverse fly, bench press, shoulder press, lateral raises, butterfly with extended arms, crunches, leg presses, leg extension and curls, leg adduction, abduction.

Other: High Intensity Resistance Training

Group B

NO INTERVENTION

No intervention will be provided in this group. The participants in this group will follow their usual daily activities.

Interventions

High Intensity Resistance Training OTHER

High intensity resistance training will be performed 3 times a day for sixteen weeks

Group A

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Both male and female
• Age more than 60 years
• Possible sarcopenia cases as defined by Asian Working Group for Sarcopenia (Handgrip strength: Male less than 26kg and Female less than 18kg, 5 time chair stand test more than/equals to 12 seconds)

You may not qualify if:

• Orthopedic surgery in last one year
• Neurological disorders like stroke etc
• History of recent fractures
• Metabolic disorders like DM etc
• Actively involved in exercise programs
• Cognitive impairment that could confound the assessment
• Wheelchair or bed bound individuals

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Abbas Institute of Medical Sciences

Muzaffarabad, Azad Kashmir, Pakistan

Location

Related Publications (3)

• Kemmler W, Kohl M, Frohlich M, Jakob F, Engelke K, von Stengel S, Schoene D. Effects of High-Intensity Resistance Training on Osteopenia and Sarcopenia Parameters in Older Men with Osteosarcopenia-One-Year Results of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST). J Bone Miner Res. 2020 Sep;35(9):1634-1644. doi: 10.1002/jbmr.4027. Epub 2020 Apr 28.

  PMID: 32270891 BACKGROUND

• Singh M, Stewart R, White H. Importance of frailty in patients with cardiovascular disease. Eur Heart J. 2014 Jul;35(26):1726-31. doi: 10.1093/eurheartj/ehu197. Epub 2014 May 26.

  PMID: 24864078 BACKGROUND

• Abdul-Hameed U, Rangra P, Shareef MY, Hussain ME. Reliability of 1-repetition maximum estimation for upper and lower body muscular strength measurement in untrained middle aged type 2 diabetic patients. Asian J Sports Med. 2012 Dec;3(4):267-73. doi: 10.5812/asjsm.34549.

  PMID: 23342225 BACKGROUND

MeSH Terms

Conditions

Sarcopenia

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Study Officials

• Mirza Obaid Baig, MSPT

  Riphah International University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 3, 2023
• First Posted: August 14, 2023
• Study Start: August 15, 2023
• Primary Completion: December 31, 2023
• Study Completion: January 19, 2024
• Last Updated: March 5, 2024

Record last verified: 2024-03

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)