Low Versus High-intensity Exercises in Sarcopenia

NCT05593471 | Completed

• 1 other identifier: SCR-22029
• Study Type: interventional
• Target: 82
• Locations: 1 country
• Sites: 1

Brief Summary

this study aims to compare the effect of high-intensity resistance exercises measured using the 10-repetition maximum versus low-intensity aerobic exercises on muscle performance, physical function and quality of life in chronic kidney patients with sarcopenia who recently recovered from COVID-19 infection

Conditions

Sarcopenia

Outcome Measures

Primary Outcomes (1)

• Quality of life (SAR QoL) questionnaire used to assess the quality of life experienced by sarcopenia patients

  In order to measure the quality of life, we used the SarQoL® questionnaire, which is a valid, consistent, and reliable, and can therefore be recommended for clinical and research purposes (Beaudart et al., 2017).

  6 weeks

Secondary Outcomes (3)

• Physical function:

  6 weeks

• Muscle power:

  6 weeks

• Muscle strength

  6 weeks

Study Arms (2)

High intensity exercises

EXPERIMENTAL

The first group (HG) received a High-intensity exercise program consisting of progressive resistance training for 30 min using dumbbells, sandbags, and TheraBand with different colors. The exercised muscles were (knee extensors, elbow flexors, chest muscles, hip adductors, abductors, abdominal muscles, back muscles, and hand grip muscles) (references). The intensity of exercise was determined by the load which was kept at 65% of the 10-repetition maximum throughout the program duration. The repetitions of each exercise were kept at a fixed value of 2 sets of 10 - 12 repetitions per session (exercises stopped if the patient reached fatigue level). For progression, the 10-repetition maximum test was performed on a weekly schedule and the amount of load was adjusted accordingly. Exercises were done in a cyclic manner where half of the selected muscles were exercised per session and the other half were exercised in the next session.

Other: high intensity exercises

low intensity aerobic exercises

EXPERIMENTAL

The second group (LG) received a low-intensity aerobic exercise program consisting of an arm ergometer, and a bicycle ergometer to train both upper and lower body muscles. Additionally, 5 minutes of regular treadmill walking was added at the beginning and the end of the exercises session as warming up and cooling down respectively. Exercises were performed in a cyclic manner where the arm and bicycle ergometers were used alternatively. The rate of perceived exertion (RPE) scale was used to monitor the intensity of the exercises to be at 3 -4 level. The actual working out time was 20 minutes plus 10 minutes for the warming up and cooling down. Sessions were performed 3 times per week for six weeks.

Other: low intensity aerobic exercises

Interventions

high intensity exercises OTHER

resistance training progressively increasing according to specific criteria (10 repetitions maximum). for the major muscles of the body

Also known as: progressive resistance training

High intensity exercises

low intensity aerobic exercises OTHER

low-intensity exercises performed using arm or leg ergometer machines

Also known as: aerobic exercises

low intensity aerobic exercises

Eligibility Criteria

• Age: 30 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Both sexes with age between 50 - 70 years old.
• CKD stages (3 and 4)
• Infected by COVID-19 and recovered (1 - 2 months)
• Score of 4 or more on SAR-QoL Questionnaire
• Patients having had a medical prescription for physical rehabilitation.

You may not qualify if:

• Patients infected again by -CoVID-19
• Any serious inflammatory, neurological, or cardiovascular diseases.
• Chronic chest disease.
• Chronic inflammatory orthopedic disorders and rheumatoid arthritis.
• Mental impairments.

Sponsors & Collaborators

• University of Hail: lead

Study Sites (1)

King Khalid Hospital

Hail, Saudi Arabia

Location

MeSH Terms

Conditions

Sarcopenia

Interventions

High-Intensity Interval Training; Exercise

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor

Study Record Dates

• First Submitted: October 20, 2022
• First Posted: October 25, 2022
• Study Start: January 15, 2023
• Primary Completion: March 15, 2023
• Study Completion: March 19, 2023
• Last Updated: March 21, 2023

Record last verified: 2023-03

Data Sharing

• IPD Sharing: Will not share

Locations

SA (1)