Detection of Microplastics and Nanoplastics in Neurosurgery Patients (DT-MiNi)

NCT05968053 | Recruiting

• 1 other identifier: DT-MiNi
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

Plastic particles are a ubiquitous pollutant in the living environment and food chain, so far, plenty of studies have reported the internal exposure of microplastics and nanoplastics in human tissues and enclosed body fluids. Neurosurgery is the only department that can open the skull. In addition to blood and cerebrospinal fluid, there are brain tissue and tumors in the presence of lesions. Whether any of these microplastics and nanoplastics are present remains a mystery. This prospective observational study will harvest biological samples of neurosurgery patients. The objective of this research is to be able to detect microplastics and nanoplastics on blood and operation samples of neurosurgery patients.

Conditions

Carotid Artery Stenosis; Glioma; Intracranial Aneurysm; Intracranial Hemorrhages; Brain Tumor

Keywords

microplastics; nanoplastics; Intracranial Aneurysm; brain tumor; Carotid Artery Stenosis

Outcome Measures

Primary Outcomes (2)

• microplastics

  Detection of microplastics in human brain tissue and the blood undergoing neurosurgery

  baseline, intraoperative

• nanoplastics

  Detection of nanoplastics in human brain tissue and the blood undergoing neurosurgery

  baseline, intraoperative

Interventions

biological samples analysis DIAGNOSTIC_TEST

biological samples analysis

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Included patients age 18-80 years with any types of neurosurgery Excluded patients refuse to participate

You may qualify if:

• Age 18-80 years
• Any type of neurosurgery

You may not qualify if:

• ·refusal of the patient to participate

Sponsors & Collaborators

• Beijing Tiantan Hospital: lead

Study Sites (1)

Beijing Tiantan Hospital, Capital Medical University

Beijing, Beijing Municipality, 100070, China

RECRUITING

MeSH Terms

Conditions

Carotid Stenosis; Glioma; Intracranial Aneurysm; Intracranial Hemorrhages; Brain Neoplasms

Condition Hierarchy (Ancestors)

Carotid Artery Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases; Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue; Intracranial Arterial Diseases; Aneurysm; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Central Nervous System Neoplasms; Nervous System Neoplasms; Neoplasms by Site

Study Officials

• Runting Li, MD

  Beijing Tiantan Hospital

  PRINCIPAL INVESTIGATOR

• Yitong Jia, MD

  Beijing Tiantan Hospital

  PRINCIPAL INVESTIGATOR

• Ke Wang, MD

  Beijing Tiantan Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Xiaolin Chen, MD

CONTACT

13810624845; cxl_bjtth@163.com

Fa Lin, MD

CONTACT

13681107240; 13681107240@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director

Study Record Dates

• First Submitted: July 6, 2023
• First Posted: August 1, 2023
• Study Start: September 25, 2023
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: January 23, 2025

Record last verified: 2025-01

Locations

CN (1)