Population-based Investigation of Aneurysm Incidence

NCT06412783 | Completed

• 1 other identifier: 2021YFC2501103
• Study Type: interventional
• Target: 4,711
• Locations: 1 country
• Sites: 1

Brief Summary

Most intracranial aneurysms are found accidentally in neurovascular imaging. And these inspection methods are limited by the problems of instrument fixation, radiation, time-consuming, contrast agent toxicity and so on. At present, blood test is an ideal alternative method for early diagnosis. Compared with imaging examination, it is economical, general screening and convenient. Blood test is simple to operate, easy to be accepted by patients, and less invasive. Early screening of aneurysms can be performed.

Conditions

Intracranial Aneurysm

Keywords

Intracranial Aneurysms; Screening; Blood test

Outcome Measures

Primary Outcomes (1)

• Specific markers are detected

  oleic acid, arachidonic acid, docasa-hexaenoic acid, interleukin 1β， interleukin 1ra, tumor necrosis factors, SOD3, PPIA, S100A8, S100A9, MPO, APOA4, THBS1.

  1hours after blood collection

Study Arms (1)

blood test group

EXPERIMENTAL

Diagnostic Test: blood test

Interventions

blood test DIAGNOSTIC_TEST

performing blood tests on the participants for specific markers.

blood test group

Eligibility Criteria

• Age: 35 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 35-75
• Individuals with normal cognitive and communication abilities
• No serious complications, such as uncontrolled hypertension, diabetes or other chronic diseases that may affect the test results.
• Basic blood test is normal or close to normal range.

You may not qualify if:

• Pregnancy
• Severe heart disease, renal insufficiency, liver dysfunction and other major diseases.
• In the past 6 months, there were strokes, or other types of intracranial tumors, infections and other diseases that may affect the screening results.
• There are metal implants, including dentures, pacemakers, etc.
• Using or recently used drugs that may affect blood biomarkers ( such as anticoagulant drugs, immunosuppressive agents, etc. ).
• There are serious mental illness or cognitive dysfunction, such as claustrophobia, unable to cooperate with the completion of the test.
• It is currently participating in other clinical trials or has participated in other clinical trials in the past 3 months.

Sponsors & Collaborators

• Beijing Tiantan Hospital: lead

Study Sites (1)

Capital Medical University Affiliated Beijing Tiantan Hospital

Beijing, Beijing Municipality, China

Location

MeSH Terms

Conditions

Intracranial Aneurysm

Interventions

Hematologic Tests

Condition Hierarchy (Ancestors)

Intracranial Arterial Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Aneurysm; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of Department of Cerebrovascular Neurosurgery

Study Record Dates

• First Submitted: November 12, 2023
• First Posted: May 14, 2024
• Study Start: October 1, 2023
• Primary Completion: November 30, 2024
• Study Completion: February 28, 2025
• Last Updated: May 16, 2025

Record last verified: 2024-05

Locations

CN (1)