Brief Summary

This study is a multi-center, prospective, registry study. This research was supported by the National Key Research and Development Program. To establish a domestic multi-center, large-scale "brain-heart comorbidity" dynamic database platform including clinical, sample database, image and other multi-dimensional information requirements, through the construction of a multi-center intelligent scientific research integration platform based on artificial intelligence. Any of newly diagnosed cardiovascular related diseases were identified via ICD-10-CM codes: I21, I22, I24 (Ischaemic heart diseases) \[i.e., ACS\], I46 (cardiac arrest), I48 (Atrial fibrillation/flutter), I50 (Heart failure), I71 (Aortic disease), I60 (subarachnoid hemorrhage), I61 (intracerebral hemorrhage), I63 (Cerebral infarction), I65 (Occlusion and stenosis of precerebral arteries), I66 (Occlusion and stenosis of cerebral arteries), I67.1 (cerebral aneurysm), I67.5 (moyamoya diseases), Q28.2 (Arteriovenous malformation of cerebral vessels). The data is stored on the brain-heart comorbidity warehouse via a physical server at the institution's data centre or a virtual hosted appliance. The brain-heart comorbidity platform comprises of a series of these appliances connected into a multicenter network. This network can broadcast queries to each appliance. Results are subsequently collected and aggregated. Once the data is sent to the network, it is mapped to a standard and controlled set of clinical terminologies and undergoes a data quality assessment including 'data cleaning' that rejects records which do not meet the brain-heart comorbidity quality standards. The brain-heart comorbidity warehouse performs internal and extensive data quality assessment with every refresh based on conformance, completeness, and plausibility (http://10.100.101.65:30080/login).

Trial Health

On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment

100,000

participants targeted

Target at P75+ for all trials

Timeline

81mo left

Started Jan 2012

Longer than P75 for all trials

Geographic Reach

1 country

14 active sites

Status

recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

21 years study duration

Study Progress68%

Jan 2012Dec 2032

Study Start

First participant enrolled

January 1, 2012

Completed

11.5 years until next milestone

First Submitted

Initial submission to the registry

July 7, 2023

Completed

20 days until next milestone

First Posted

Study publicly available on registry

July 27, 2023

Completed

9.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2032

Expected

Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2032

Last Updated

September 21, 2023

Status Verified

September 1, 2023

Enrollment Period

21 years

First QC Date

July 7, 2023

Last Update Submit

September 16, 2023

Conditions

Ischemic Heart Disease Cardiac Arrest Atrial Fibrillation Heart Failure Aortic Diseases Subarachnoid Hemorrhage Intracerebral Hemorrhage Cerebral Infarction Occlusion and Stenosis of Precerebral Arteries Occlusion and Stenosis of Cerebellar Arteries Cerebral Aneurysm Moyamoya Disease Arteriovenous Malformation of Cerebral Vessels

Outcome Measures

Primary Outcomes (3)

Rate of Participants with Composite of All-Cause Mortality and Cardiovascular Outcomes
The occurrence of all-cause mortality, coronary artery disease event, stroke (ischemic or hemorrhagic), heart failure, or atrial fibrillation etc.
At discharge/30 days
All-Cause Mortality
The occurrence of death
At discharge/30 days
Rate of Participants with Composite of Cardiovascular Outcomes
The occurrence of coronary artery disease event, stroke (ischemic or hemorrhagic), heart failure, or atrial fibrillation etc.
At discharge/30 days

Interventions

Multi-disciplinary assessmentOTHER

Multi-disciplinary assessment

Eligibility Criteria

Age18 Years+

Sexall

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Inclusion Criteria: * age \> 18 years old * Any of newly diagnosed cardiovascular-related diseases were identified via ICD-10-CM codes: I21, I22, I24 (Ischaemic heart diseases) \[i.e., ACS\], I46 (cardiac arrest), I48 (Atrial fibrillation/flutter), I50 (Heart failure), I71 (Aortic disease), I60 (subarachnoid hemorrhage), I61 (intracerebral hemorrhage), I63 (Cerebral infarction), I65 (Occlusion and stenosis of precerebral arteries), I66 (Occlusion and stenosis of cerebral arteries), I67.1 (cerebral aneurysm), I67.5 (moyamoya diseases), Q28.2 (Arteriovenous malformation of cerebral vessels). Exclusion Criteria: ·refuse to participate in the registry

You may qualify if:

age \> 18 years old
Any of newly diagnosed cardiovascular-related diseases were identified via ICD-10-CM codes: I21, I22, I24 (Ischaemic heart diseases) \[i.e., ACS\], I46 (cardiac arrest), I48 (Atrial fibrillation/flutter), I50 (Heart failure), I71 (Aortic disease), I60 (subarachnoid hemorrhage), I61 (intracerebral hemorrhage), I63 (Cerebral infarction), I65 (Occlusion and stenosis of precerebral arteries), I66 (Occlusion and stenosis of cerebral arteries), I67.1 (cerebral aneurysm), I67.5 (moyamoya diseases), Q28.2 (Arteriovenous malformation of cerebral vessels).

You may not qualify if:

·refuse to participate in the registry

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Beijing Tiantan Hospitallead

Study Sites (14)

Beijing Tiantan Hospital, Capital Medical University

Beijing, Beijing Municipality, 100070, China

RECRUITING

Beijing Anzhen Hospital, Capital Medical University