NCT02664818

Brief Summary

The purpose of this study is to assess clinical characteristics, treatment, and outcome of patients hospitalized with heart failure in China and compared those with other registries

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
15,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2012

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2012

Completed
4 years until next milestone

First Submitted

Initial submission to the registry

January 11, 2016

Completed
16 days until next milestone

First Posted

Study publicly available on registry

January 27, 2016

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2016

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2016

Completed
Last Updated

January 27, 2016

Status Verified

January 1, 2016

Enrollment Period

4.3 years

First QC Date

January 11, 2016

Last Update Submit

January 22, 2016

Conditions

Heart Failure

Keywords

Heart failureChinaRegistryCharacteristicOutcome

Outcome Measures

Primary Outcomes (1)

  • The overall composite of 9 performance measures for heart failure medications compliance.

    1. Prescribed rate of ACEIs/ARBs in patients with acute decompensated heart failure (ADHF) before admission. 2. Prescribed rate of β blockers in patients with ADHF before admission. 3. Prescribed rate of diuretics in patients with ADHF before admission. 4. Prescribed rate of aldosterones in patients with ADHF before admission. 5. Prescribed rate of ACEIs/ARBs in appropriate patients discharged alive. 6. Prescribed rate of β blockers in appropriate patients discharged alive. 7. Prescribed rate of diuretics in all patients discharged alive. 8. Prescribed rate of aldosterones in appropriate patients discharged alive. 9. Prescribed rate of warfarins in patients with nonvalvular atrial fibrillation and CHA2DS2-VASc score ≥2 discharged alive.

    Duration of hospital stay, an expected average of 10 days

Secondary Outcomes (1)

  • Number of deaths during index of hospitalization and after discharge.

    Duration of hospital stay with an expected average of 10 days for in-hospital death; 1 year for patients discharged alive

Study Arms (1)

Heart failure

Hospitalized patients with primary discharge diagnosis of heart failure and who were aged 18 years or older.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients hospitalized with primary discharge diagnosis of heart failure

You may qualify if:

  • Hospitalized patients with primary discharge diagnosis of heart failure according to current Chinese Heart Failure Guideline were recruited from January 2012.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College

Beijing, Beijing Municipality, 100037, China

RECRUITING

Related Publications (7)

  • Wu Y, Zhang Y, Zhang J. Low Aortic Pulsatility Index and Pulmonary Artery Pulsatility Index Are Associated With Increased Mortality in Patients With Dilated Cardiomyopathy Awaiting Heart Transplantation. Korean Circ J. 2025 Feb;55(2):134-147. doi: 10.4070/kcj.2024.0192. Epub 2024 Oct 17.

    PMID: 39506184DERIVED

  • Huang BP, Zhao L, Zhao XM, Zhai M, Huang Y, Zhou Q, Tian PC, Liang L, Huang LY, Feng JY, Zhang YH, Zhang J. Serum Potassium Levels and Mortality in Hospitalized Heart Failure Patients. Rev Cardiovasc Med. 2023 Aug 9;24(8):228. doi: 10.31083/j.rcm2408228. eCollection 2023 Aug.

    PMID: 39076700DERIVED

  • Huang B, Huang Y, Zhai M, Zhou Q, Ji S, Liu H, Zhuang X, Zhang Y, Zhang J. Association of Sex With Cardiovascular Outcomes in Heart Failure Patients With Obstructive or Central Sleep Apnea. J Am Heart Assoc. 2024 Mar 5;13(5):e031186. doi: 10.1161/JAHA.123.031186. Epub 2024 Feb 27.

    PMID: 38410942DERIVED

  • Wu Y, Tian P, Liang L, Chen Y, Feng J, Huang B, Huang L, Zhao X, Wang J, Guan J, Li X, Zhang Y, Zhang J. Afterload-related cardiac performance is a powerful hemodynamic predictor of mortality in patients with chronic heart failure. Ther Adv Chronic Dis. 2023 Jun 5;14:20406223231171554. doi: 10.1177/20406223231171554. eCollection 2023.

    PMID: 37324410DERIVED

  • Zhao L, Zhao X, Tian P, Liang L, Huang B, Huang L, Feng J, Zhang Y, Zhang J. Predictive value of remnant cholesterol level for all-cause mortality in heart failure patients. Front Cardiovasc Med. 2023 Feb 15;10:1063562. doi: 10.3389/fcvm.2023.1063562. eCollection 2023.

    PMID: 36873397DERIVED

  • Liang L, Zhao X, Huang L, Tian P, Huang B, Feng J, Zhou P, Wang J, Zhang J, Zhang Y. Prevalence and prognostic importance of malnutrition, as assessed by four different scoring systems, in elder patients with heart failure. Nutr Metab Cardiovasc Dis. 2023 May;33(5):978-986. doi: 10.1016/j.numecd.2023.01.004. Epub 2023 Jan 11.

    PMID: 36710105DERIVED

  • Zhao L, Zhao X, Tian P, Liang L, Huang B, Huang L, Feng J, Zhang Y, Zhang J. Prognostic utility of the prognostic nutritional index combined with serum sodium level in patients with heart failure. Nutr Metab Cardiovasc Dis. 2022 Aug;32(8):1894-1902. doi: 10.1016/j.numecd.2022.04.004. Epub 2022 Apr 14.

    PMID: 35637081DERIVED

Related Links

MeSH Terms

Conditions

Heart Failure

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Study Officials

  • Jian Zhang, Ph. D

    Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College

    STUDY CHAIR

Central Study Contacts

Rongcheng Zhang, Ph. D

CONTACT

86 (10) 8839 8170zrc1982916@163.com

Yunhui Zhang, Ph. D

CONTACT

86 (10) 8839 8170yuhuizhangjoy@163.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
1 Year
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Director of Heart Failure Center, Fuwai hospital; vice-chairmen of Chinese Heart Failure Association

Study Record Dates

First Submitted

January 11, 2016

First Posted

January 27, 2016

Study Start

January 1, 2012

Primary Completion

April 1, 2016

Study Completion

December 1, 2016

Last Updated

January 27, 2016

Record last verified: 2016-01

Data Sharing

IPD Sharing
Will share

Data were abstracted by printed Case Report Form and entered into a web-based data center (http://103.31.202.60/subFW/). Hospitals that did not complete electronic CRF (eCRF) would send printed CRF to data center. Trained clinicians or staffs would enter these data into web-based eCRF.

Locations

CN(1)