Functional Magnetic Resonance-Based Observations of Brain Networks in Moyamoya Disease Patients Under Anesthesia

NCT06041659 | Recruiting

• 1 other identifier: 2023022
• Study Type: observational
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

Moyamoya disease is characterized by progressive stenosis of the genesis of the distal internal carotid arteries bilaterally and progressive generation of compensatory pathological vascular networks at the basis cranii, and these pathological vasculature has poor vascular reactivity. Perioperative circulatory management of patients with smoky vessels to ensure perfusion of brain tissue and integrity of brain network during surgery to minimize postoperative impairment of neurological functions, including motor, sensory, emotional and cognitive functions, is the key point of perioperative circulatory management of moyamoya disease. Functional Magnetic Resonance Imaging (fMRI) has been routinely used in various cerebrovascular diseases to further evaluate cerebrovascular reserve and cerebral network connectivity. The purpose of this study is to observe the changes in cerebral blood flow, cerebral oxygen metabolism, cerebral oxygen metabolism rate, and cerebral network connectivity in adult patients with moyamoya disease in cerebral ischemia-sensitive areas under anesthesia to provide a basis for exploring anesthesia management to improve cognitive function and cerebral network connectivity in these patients.

Conditions

Moyamoya Disease

Keywords

Moyamoya Disease; Cerebral Network; Cognitive Function; Anesthesia

Outcome Measures

Primary Outcomes (1)

• Changes of brain functional network

  Before sedation, after sedation and after maintenan the blood pressure at baseline 100%-120% for 15min

Secondary Outcomes (2)

• Postoperative delirium

  Day1-5 after surgery

• Electroencephalogram changes

  Before sedation, after sedation and after maintenan the blood pressure at baseline 100%-120% for 15min

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We plan to recruit consecutive patients with moyamoya disease who are to undergo direct or indirect revascularization surgery from August 2023 to December 2025 at Beijing Tiantan Hospital of Capital Medical University.

You may qualify if:

• Patients with moyamoya disease scheduled for direct or indirect intracranial and extracranial revascularization surgery
• Age between 18-65 years
• Obtain written informed consent.

You may not qualify if:

• Patients with preoperative claustrophobia, sensory or motor aphasia that are unable to understand and cooperate with the examination
• Preoperative cranial imaging suggesting cerebral infarction lesion diameter \>15mm
• Patients allergic to anesthetic drugs
• Metal implants in the body
• Undergoing other experimental drug or instrumentation trials

Sponsors & Collaborators

• Beijing Tiantan Hospital: lead

Study Sites (1)

Beijing Tiantan Hospital, Capital Medical University

Beijing, Beijing Municipality, 100070, China

RECRUITING

MeSH Terms

Conditions

Moyamoya Disease

Condition Hierarchy (Ancestors)

Carotid Artery Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Cerebral Arterial Diseases; Intracranial Arterial Diseases; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Shu Li

  Beijing Tiantan Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Shu Li

CONTACT

8613699223065; lishu@bjtth.org

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor

Study Record Dates

• First Submitted: September 11, 2023
• First Posted: September 18, 2023
• Study Start: October 24, 2023
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: February 13, 2025

Record last verified: 2025-02

Locations

CN (1)