Magnesium as an Adjuvant Agent for Postoperative Pain
1 other identifier
interventional
50
1 country
1
Brief Summary
Participants are being asked to participate in this research study because they have elected to undergo periacetabular osteotomy (PAO). This research study is looking at if using IV magnesium during surgery can help to reduce pain after surgery.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_4
Started Mar 2025
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 5, 2023
CompletedFirst Posted
Study publicly available on registry
July 17, 2023
CompletedStudy Start
First participant enrolled
March 10, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 31, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
August 31, 2026
April 21, 2026
April 1, 2026
1.5 years
July 5, 2023
April 17, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Change in pain as measured by the Visual Analog Scale (VAS)
The VAS is a scale from 0-10 with 0 being no pain and 10 being the worst pain ever
Over the first 7 days post operatively, measured every 6 hours
Change in number of narcotic medications consumed as measured by the medical record review
Over the first 7 days post operatively, gathered every 6 hours.
Secondary Outcomes (2)
Change in PROMIS scores
2 weeks, 6 weeks, 3 months, 6 months, 1 year
Change in modified Harris Hip Scores (mHHS)
2 weeks, 6 weeks, 3 months, 6 months, 1 year
Study Arms (2)
IV Magnesium Sulfate adjuvant group
EXPERIMENTALParticipants in this group will receive standard-of-care procedures intraoperatively and postoperatively along with IV magnesium sulfate for pain control.
Control group
NO INTERVENTIONParticipants in this group will receive standard-of-care procedures intraoperatively and post-operatively for pain control.
Interventions
Participants will receive IV Magnesium Sulfate intraoperatively.
Eligibility Criteria
You may qualify if:
- Patients undergoing periacetabular osteotomy with or without adjuvant hip arthroscopy
You may not qualify if:
- illiterate or non-English speaking patients
- patients with 2nd or 3rd degree AV block
- patients with severe renal insufficiency
- patients with heart failure
- patients with bradycardia
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University Hospitals
Cleveland, Ohio, 44106, United States
Related Publications (1)
Sinkler MA, Nighswander AJ, Smith KL, Fortier LM, Kodsy MM, Fanaeian E, Salata MJ, Wetzel RJ. MAGNA-PAO: magnesium as an adjuvant for postoperative analgesia in periacetabular osteotomy; a clinical trial protocol. Pain Manag. 2026 Mar 16:1-7. doi: 10.1080/17581869.2026.2645536. Online ahead of print.
PMID: 41837581DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Robert Wetzel, MD
University Hospitals
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- SUPPORTIVE CARE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Orthopedic Trauma Surgeon
Study Record Dates
First Submitted
July 5, 2023
First Posted
July 17, 2023
Study Start
March 10, 2025
Primary Completion (Estimated)
August 31, 2026
Study Completion (Estimated)
August 31, 2026
Last Updated
April 21, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will not share