Study of Biomarkers of Heat Tolerance and Recovery During Ultra-endurance Exercise

NCT05921864 | Completed

• 2 other identifiers: 2023PBMD052023-A00730-45
• Study Type: observational
• Target: 11
• Locations: 1 country
• Sites: 1

Brief Summary

Military personnel are called upon to serve in hot, dry or humid climates, which places great demands on their ability to tolerate heat. Induced heat stress can impair performance and lead to pathologies. Faced with the challenges of global warming, this issue is becoming increasingly important in the practice of sport. While hyperthermia is known to impair endurance performance, the underlying thermophysiological responses and regulatory mechanisms during prolonged exercise remain poorly understood. The effects of hyperthermia on mental performance raise questions about the degradation of interoceptive capacities and the deleterious impact on behavioral regulation, an important component of thermal risk management in ultra-endurance exercise. What's more, despite the muscular and hydromineral consequences (rhabdomyolysis, renal failure, dehydration) of prolonged exercise, few data are available on recovery kinetics. A better understanding of the factors conditioning recovery quality could help limit the deleterious consequences of ultra-endurance exercise.

Conditions

Heat Stress; Heat

Keywords

ultra-endurance

Outcome Measures

Primary Outcomes (1)

• Degree of correlation between core temperature measured at the end of passive heat exposure and that measured at the end of active heat exposure

  Core temperature will be measured in every participants at the end of passive heat exposure and at the end of active heat exposure. A correlation analysis will be performed on these measurements.

  Through study completion (1 month)

Interventions

Passive heat exposure OTHER

Participants will be exposed to heat in a chamber.

Active heat exposure OTHER

Participants will participate to a 6-hour run.

Eligibility Criteria

• Age: 18 Years - 37 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study population will be composed of healthy young athletes.

You may qualify if:

• Healthy individuals
• BMI between 18 and 25 kg/m2
• Weight ≥ 51 kg
• Minimum training volume 6 days/7, aerobic
• Participation in a running competition ≥ 6hours
• Having given informed consent

You may not qualify if:

• Presence or history of medical pathology
• Presence of significant deviation from normal electrocardiogram values
• History of heat stroke
• Known intolerance to heat
• Inability to swallow a capsule or refusal of rectal probe
• Alcohol consumption exceeding the equivalent of 3 glasses of wine per week
• Consumption of narcotics
• Smoking \> 0.5 pack of cigarettes per day
• On usual medication
• Pregnant or breast-feeding women
• Protected adult, under legal protection, guardianship or curatorship, or unable to give personal written consent

Sponsors & Collaborators

• Direction Centrale du Service de Santé des Armées: lead

Study Sites (1)

Institut de Recherche Biomédicale des Armées

Brétigny-sur-Orge, 91223, France

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood and urine samples

MeSH Terms

Conditions

Heat Stress Disorders

Condition Hierarchy (Ancestors)

Wounds and Injuries

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 16, 2023
• First Posted: June 27, 2023
• Study Start: June 19, 2023
• Primary Completion: July 22, 2023
• Study Completion: July 22, 2023
• Last Updated: September 8, 2023

Record last verified: 2023-09

Locations

FR (1)