Assessment of the Effects of a 24-hour Cold and Heat Exposure on the Factors Influencing Food Intake

NCT05584527 | Unknown

• 2 other identifiers: 2021PBMD082022-A01862-41
• Study Type: observational
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

Military personnel and athletes have a very high energy expenditure which is increased during certain key periods (intense training, competition and mission). Compensating for this expenditure through food can be complicated by physiological ingestive limits and logistical and organizational constraints (number of meals, availability of food), which leads these populations to regularly experience energy deficit situations (intake below requirements), which could alter physical and cognitive performance and major physiological functions. Among the many constraints to which military personnel and athletes are exposed to (stress, sleep deprivation, travel, etc.) that can increase the risk of energy deficits, the impact of thermal environmental constraints is not well known. The seasonal impact and travel to countries with very different thermal environments can lead these populations to experience cold and hot conditions for long periods. Understanding how heat and cold exposure modifies appetite and energy intake therefore appears to be of great importance. The hypothesis of this study is that a 24 h heat exposure would produce a rapid and long-lasting anorexigenic action impacting energy intake, while a cold exposure would produce the opposite effect (orexigenic action).

Conditions

Eating Habit; Cold Exposure; Heat

Keywords

Heat Exposure; Food Intake

Outcome Measures

Primary Outcomes (1)

• Total energy intake (in kilojoules) measured at the end of each condition (heat exposure, cold exposure and thermoneutral exposure)

  Through study completion (30 months)

Interventions

Heat exposure (32°C) OTHER

The participants will be exposed to heat (32°C) for 24 hours in a climatic apartment. During the exposure, * food intake and energy expenditure will be measured * several physiological tests will be performed: hunger and thirst questionnaires, thermal sensations, skin temperature measurement, weighing, olfactory and gustatory capacities, food preference questionnaire, etc. * sleep brain activity will be monitored using a headband * urine and saliva samples will be collected.

Cold exposure (16°C) OTHER

The participants will be exposed to cold (16°C) for 24 hours in a climatic apartment. During the exposure, * food intake and energy expenditure will be measured * several physiological tests will be performed: hunger and thirst questionnaires, thermal sensations, skin temperature measurement, weighing, olfactory and gustatory capacities, food preference questionnaire, etc. * sleep brain activity will be monitored using a headband * urine and saliva samples will be collected.

Thermoneutral exposure (24°C) OTHER

The participants will be exposed to a thermoneutral environment (24°C) for 24 hours in a climatic apartment. During the exposure, * food intake and energy expenditure will be measured * several physiological tests will be performed: hunger and thirst questionnaires, thermal sensations, skin temperature measurement, weighing, olfactory and gustatory capacities, food preference questionnaire, etc. * sleep brain activity will be monitored using a headband * urine and saliva samples will be collected.

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study population will be composed of young and healthy men.

You may qualify if:

• Male
• Aged 18 to 40 years old
• Active (≥ 3 hours of physical activity per week)
• Healthy (no metabolic pathology)
• Affiliated to the social security system
• Having given written consent to participate.

You may not qualify if:

• Unusual eating pattern (\< 3 meals per day) or irregular eating pattern
• Pattern of dietary restriction (determined by the Three-Factor Eating Questionnaire-21)
• Unusual sleep pattern (Epworth score \> 10, insomnia severity score \> 14, Pittsburgh Sleep Quality Index \> 5), sleep duration \< 6 h per night or difficulty falling asleep)
• Metabolic pathology
• On medication
• Refusal to participate.

Sponsors & Collaborators

• Direction Centrale du Service de Santé des Armées: lead

Study Sites (1)

Institut de Recherche Biomédicale des Armées

Brétigny-sur-Orge, 91223, France

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

Saliva and blood samples will be collected during each experimental visit : * saliva samples will be collected to measure salivary cortisol level. * blood samples will be collected to measure plasma levels of acylated ghrelin, leptin, peptide YY and Glucagon-like peptide-1.

MeSH Terms

Conditions

Feeding Behavior

Condition Hierarchy (Ancestors)

Behavior, Animal; Behavior

Central Study Contacts

Keyne CHARLOT, PhD

CONTACT

178651303; keyne.charlot@intradef.gouv.fr

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 14, 2022
• First Posted: October 18, 2022
• Study Start: November 28, 2022
• Primary Completion: May 1, 2025
• Study Completion: May 1, 2025
• Last Updated: December 9, 2022

Record last verified: 2022-12

Locations

FR (1)