Short- and Long-term Health Consequences of Workers During Consecutive Days of Heat Stress

NCT05302674 | Completed

• 1 other identifier: STUDY00005847
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to measure fatigue and indicators of acute kidney injury during consecutive days of work in a hot environment.

Conditions

Heat Stress; Fatigue

Outcome Measures

Primary Outcomes (2)

• Change from baseline in fatigue

  Fatigue will be measured using accelerometry, with the primary variable being jerk, the smoothness or unevenness of movement.

  Hour 4

• Biomarkers of acute kidney injury

  Tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) are biomarkers that have the potential for early prediction of acute kidney injury.

  Hour 4

Study Arms (1)

Hot Dry

EXPERIMENTAL

The participant will complete four hours of work at a 45:15 work rest cycle in a 98°F (36.7°C) and 20% relative humidity environment.

Other: Hot Dry

Interventions

Hot Dry OTHER

98°F (36.7°C) and 20% relative humidity environment

Hot Dry

Eligibility Criteria

• Age: 18 Years - 39 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy individuals
• Regularly completes aerobic exercise at least 60 min per week

You may not qualify if:

• History of cardiovascular, metabolic, respiratory, neural, or renal disease
• Hypertensive or tachycardic during the screening visit (Systolic Blood Pressure \> 139 mmHg, Diastolic Blood Pressure \> 89 mmHg, heart rate \> 100 bpm)
• Current tobacco or nicotine use or previous regular use within the past 2 years
• Current or previous musculoskeletal injury limiting physical activity
• Taking medications with known thermoregulatory or cardiovascular effects (e.g., aspirin, beta blockers, diuretics, psychotropics, etc.)
• A positive pregnancy test at any point during the study or currently breastfeeding
• Study physician discretion based on any other medical condition or medication

Sponsors & Collaborators

• State University of New York at Buffalo: lead

Study Sites (1)

Center for Research and Education in Special Environments

Buffalo, New York, 14214, United States

Location

MeSH Terms

Conditions

Heat Stress Disorders; Fatigue

Condition Hierarchy (Ancestors)

Wounds and Injuries; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Riana R Pryor, PhD

  University at Buffalo

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: March 11, 2022
• First Posted: March 31, 2022
• Study Start: April 1, 2022
• Primary Completion: March 14, 2024
• Study Completion: March 14, 2024
• Last Updated: June 17, 2024

Record last verified: 2024-06

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)