Gait Control in Parkinson Disease

NCT05908279 | Recruiting

• 1 other identifier: GAIT-PD
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Previous work has shown that a statistical property of gait characterised by long-range autocorrelation functions is altered in Parkinson disease (PD). On the other hand it has been suggested that the same property is linked to the ability in healthy humans to co-regulate the amplitude and cadence of strides towards maintaining a constant speed. Here the investigators want to better understand why it is altered in PD by measuring the transitions between gait instructed by a metronome, and gait without metronome. The experimental conditions will allow the comparisons between these transitions across PD and healthy groups of volunteers, and assess differences based on statistical and computational modelling. The link with potential freezing episodes will also be studied to assess whether the statistical determinants of gait control in this population can be used as a proxy or predictor of the occurence of freezing episodes.

Conditions

Parkinson Disease

Outcome Measures

Primary Outcomes (2)

• Stride cadence

  Time between two consecutive heel strikes. Units are seconds.

  Measured during the entire experiment (an average of 4.5 years)

• Stride amplitude

  Distance between two consecutive heel strikes. Units are meters.

  Measured during the entire experiment (an average of 4.5 years)

Study Arms (2)

PD

Patients with Parkinson's disease

Other: Walking test; Other: Disease assessement

Control

Healthy volunteers

Other: Walking test

Interventions

Walking test OTHER

Walk with and without a metronome

Control; PD

Disease assessement OTHER

Disease stage assessed by a doctor

PD

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

One group of volunteers with previous diagnosis of Parkinson disease and one group of age and sex matched healthy volunteers.

You may qualify if:

• Patients and volunteers able to walk for 20mins and without other neurological disorders.

You may not qualify if:

• Patients or volunteers unable to walk for 20mins and with other neurological disorders.

Sponsors & Collaborators

• Université Catholique de Louvain: lead

Study Sites (1)

Université catholique de Louvain

Louvain-la-Neuve, 1348, Belgium

RECRUITING

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Frederic Crevecoeur

  Université Catholique de Louvain

  STUDY DIRECTOR

Central Study Contacts

André Mouraux, PhD

CONTACT

+32 2 764 54 47; andre.mouraux@uclouvain.be

Frederic Crevecoeur

CONTACT

frederic.crevecoeur@uclouvain.be

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 25, 2023
• First Posted: June 18, 2023
• Study Start: May 1, 2023
• Primary Completion (Estimated): October 31, 2027
• Study Completion (Estimated): October 31, 2027
• Last Updated: June 18, 2023

Record last verified: 2023-06

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)