Flexible Reaching Control in Parkinson Disease

NCT05908266 | Recruiting

• 1 other identifier: REACH-PD
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Current research and theories have highlighted that the parameters linked to movement planning, e.g. the decision to select a movement goal, and adaptation, e.g. the ability to update control dependent on a novel dynamical context, are update quickly and within an ongoing movement in the general population. In parallel, it has been suggested that the evaluation of movement costs is a function of the basal ganglia, and it is impaired in Parkinson disease (PD). Here the investigators want to test whether these mechanisms also alter the ability of patients to update control during an ongoing action. A positive result would confirm that movement-related costs and dynamical representations depend on the integrity of the basal ganglia, in contrast a negative result would indicate that the deficit in PD is more specifically related to movement initiation, which would invite one to reconsider the cause of bradykinesia in this population.

Conditions

Parkinson Disease

Outcome Measures

Primary Outcomes (3)

• Kinematics

  Position of the handle as a function of time. Units are millimetres

  Measured during the entire experiment (an average of 4.5 years)

• Surface Electromyogram

  Surface recordings of muscles activities from the main muscles involved in movement production. Units are volts

  Measured during the entire experiment (an average of 4.5 years)

• Applied forces

  Forces applied by participants on the robotic handle. Units are Newtons

  Measured during the entire experiment (an average of 4.5 years)

Study Arms (2)

PD

Patients with Parkinson disease

Other: Reaching movements; Other: Disease Assessment

Control

Healthy volunteers

Other: Reaching movements

Interventions

Reaching movements OTHER

Participants will be instructed to perform reaching movements by moving the handle of a robotic arm mounted with a virtual reality display.

Control; PD

Disease Assessment OTHER

Disease stage assessed by trained professionals

PD

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study will be based on two populations: on population of volunteers with Parkinson disease, and one population of age and sex matched healthy individuals.

You may qualify if:

• Ability to perform the task (assessed during the experiment)

You may not qualify if:

• Inability to perform the task (motor) or to understand the task requirements (cognitive)

Sponsors & Collaborators

• Université Catholique de Louvain: lead

Study Sites (1)

Université catholique de Louvain

Louvain-la-Neuve, 1348, Belgium

RECRUITING

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Frédéric Crevecoeur, PhD

  Université Catholique de Louvain

  STUDY DIRECTOR

Central Study Contacts

André Mouraux, PhD

CONTACT

+32 2 764 54 47; andre.mouraux@uclouvain.be

Frédéric Crevecoeur, PhD

CONTACT

frederic.crevecoeur@uclouvain.be

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 25, 2023
• First Posted: June 18, 2023
• Study Start: May 1, 2023
• Primary Completion (Estimated): October 31, 2027
• Study Completion (Estimated): October 31, 2027
• Last Updated: June 18, 2023

Record last verified: 2023-06

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)