NCT04314973

Brief Summary

The goal of this study is to develop and validate a haptic assistive method in order to support walking in patients with Parkinson's disease, delivered to the patient's hips through a wearable robotic pelvis orthosis.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
41

participants targeted

Target at P50-P75 for not_applicable parkinson-disease

Timeline
Completed

Started Jan 2022

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 11, 2020

Completed
8 days until next milestone

First Posted

Study publicly available on registry

March 19, 2020

Completed
1.9 years until next milestone

Study Start

First participant enrolled

January 27, 2022

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2023

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2023

Completed
Last Updated

June 21, 2022

Status Verified

June 1, 2022

Enrollment Period

11 months

First QC Date

March 11, 2020

Last Update Submit

June 14, 2022

Conditions

Keywords

ExoskeletonActive Pelvis Orthosis

Outcome Measures

Primary Outcomes (1)

  • Long-Range Autocorrelation (LRA)

    Assesses the variability between stride durations

    From day 0 up to 8 weeks

Secondary Outcomes (7)

  • Unified Parkinson's disease rating scales (UPDRS)

    From day 0 up to 8 weeks

  • Activities-Specific Balance Confidence Scale (ABC)

    From day 0 up to 8 weeks

  • Balance Evaluation Systems Test (BESTest)

    From day 0 up to 8 weeks

  • Gait analysis

    From day 0 up to 8 weeks

  • Joint torques

    From day 0 up to 8 weeks

  • +2 more secondary outcomes

Study Arms (2)

Evaluation sessions

ACTIVE COMPARATOR

Patients will be evaluated while walking without wearing the robotic device, once before the intervention phase, once right after, and once a month after.

Other: Walking exercises

Intervention phase

EXPERIMENTAL

Patients will walk with the robotic device, for 12 sessions of 10 min.

Device: Active Pelvis Orthosis

Interventions

Walking with the robotic device providing the assistive protocol.

Intervention phase

Walking exercises without wearing the robotic device.

Evaluation sessions

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Parkinson's disease diagnosis positive according to UK Brain Bank criteria
  • Hoehn and Yahr score of 1 to 3
  • Mini-mental state (MMSE) higher than 24
  • No contraindication to physical exercising (ACSM criteria)

You may not qualify if:

  • Not being able to understand French well enough
  • Not being in the targeted age range

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Cliniques universitaires Saint-Luc

Brussels, 1200, Belgium

Location

Related Publications (1)

  • Otlet V, Vandamme C, Warlop T, Crevecoeur F, Ronsse R. Effects of overground gait training assisted by a wearable exoskeleton in patients with Parkinson's disease. J Neuroeng Rehabil. 2023 Nov 16;20(1):156. doi: 10.1186/s12984-023-01280-y.

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian DisordersBasal Ganglia DiseasesBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesMovement DisordersSynucleinopathiesNeurodegenerative Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 11, 2020

First Posted

March 19, 2020

Study Start

January 27, 2022

Primary Completion

January 1, 2023

Study Completion

June 1, 2023

Last Updated

June 21, 2022

Record last verified: 2022-06

Data Sharing

IPD Sharing
Will not share

Locations