NCT05875051

Brief Summary

Reduced-exertion high-intensity training (REHIT) is a novel form of exercise known for being non-classical, time-efficient, and effective on different populations. However, REHIT was scarcely tested on sedentary women with mortality risks. The aim of the study is to compare the effects of REHIT versus short moderate-intensity training (SMIT) on functional capacity, resting heart rate (RHR), and activity enjoyment in sedentary young women.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Dec 2021

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2021

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 30, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2022

Completed
1 year until next milestone

First Submitted

Initial submission to the registry

May 16, 2023

Completed
9 days until next milestone

First Posted

Study publicly available on registry

May 25, 2023

Completed
Last Updated

May 25, 2023

Status Verified

May 1, 2023

Enrollment Period

5 months

First QC Date

May 16, 2023

Last Update Submit

May 24, 2023

Conditions

Sedentary Behavior

Keywords

High-intensity trainingModerate intensity trainingSedentary young women

Outcome Measures

Primary Outcomes (2)

  • Functional capacity

    It will be measured using the 6-minutes walking test (6MWT). Participants will be instructed to walk as quickly as possible along a 30-meter hallway for a duration of six minutes without running. Then, the distance in meters they cover will be registered. The greater the number of meters run, the better the functional capacity.

    Baseline

  • Functional capacity

    It will be measured using the 6-minutes walking test (6MWT). Participants will be instructed to walk as quickly as possible along a 30-meter hallway for a duration of six minutes without running. Then, the distance in meters they cover will be registered. The greater the number of meters run, the better the functional capacity.

    After the intervention (3 weeks)

Secondary Outcomes (4)

  • Resting heart rate

    Baseline

  • Resting heart rate

    After the intervention (3 weeks)

  • Physical activity enjoyment

    Baseline

  • Physical activity enjoyment

    After the intervention (3 weeks)

Study Arms (2)

Reduced-exertion high intensity training group

EXPERIMENTAL

The REHIT part will consist of maximum cycling sprints of all-out exercise at 100% of the HRmax, increasing for up to 10 seconds, 15 seconds on week two and 20 seconds on week three.

Other: Reduced-exertion high intensity training

Short moderate intensity training group

ACTIVE COMPARATOR

The SMIT part of the session will consist of 6 minutes of moderate intensity exercise at 60-70% HRmax.

Other: Short moderate intensity training

Interventions

Reduced-exertion high intensity trainingOTHER

The intervention of the REHIT group will consist of three parts: i) 3 minutes of warm-up part at 50% of HRmax obtained in the effort test; ii) 3 min 20 sec to 3 min 40 sec of REHIT; and iii) 3 minutes of cool-down at 50% of HRmax obtained in the effort test. The REHIT part will consist of maximum cycling sprints of all-out exercise at 100% of the HRmax, increasing for up to 10 seconds, 15 seconds on week two and 20 seconds on week three. Then, 3 minutes of active rest at 50% of HRmax. Finally, 10 seconds of all-out exercise at 100% of the HRmax, rising to 15 seconds on week two and 20 seconds on week three.

Reduced-exertion high intensity training group
Short moderate intensity trainingOTHER

The SMIT group will receive a short moderate-intensity training with the same warm-up and cool-down exercises as the REHIT group. In addition, the main part of the session consisted of 6 minutes of moderate intensity exercise at 60-70% HRmax obtained in the effort test. In addition, the main part of the session increases 3 min every week as 6 min for the first 2 weeks, 9 min for the 3rd and 4th weeks, and 12 min for the last two weeks.

Short moderate intensity training group

Eligibility Criteria

Age18 Years - 25 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Women.
  • Age between 18 and 25 years old.
  • Those who score a low physical activity level (\< 600 METS min/week) in the International Physical Activity Questionnaire-short form.

You may not qualify if:

  • Women who suffer from musculoskeletal.
  • Women who suffer from neurological diseases.
  • Those who are taking medications.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Valencia

Valencia, 46010, Spain

Location

Related Publications (4)

  • Metcalfe RS, Atef H, Mackintosh K, McNarry M, Ryde G, Hill DM, Vollaard NBJ. Time-efficient and computer-guided sprint interval exercise training for improving health in the workplace: a randomised mixed-methods feasibility study in office-based employees. BMC Public Health. 2020 Mar 12;20(1):313. doi: 10.1186/s12889-020-8444-z.

    PMID: 32164631BACKGROUND

  • Ramirez-Velez R, Hernandez-Quinones PA, Tordecilla-Sanders A, Alvarez C, Ramirez-Campillo R, Izquierdo M, Correa-Bautista JE, Garcia-Hermoso A, Garcia RG. Effectiveness of HIIT compared to moderate continuous training in improving vascular parameters in inactive adults. Lipids Health Dis. 2019 Feb 4;18(1):42. doi: 10.1186/s12944-019-0981-z.

    PMID: 30717757BACKGROUND

  • Metcalfe RS, Tardif N, Thompson D, Vollaard NB. Changes in aerobic capacity and glycaemic control in response to reduced-exertion high-intensity interval training (REHIT) are not different between sedentary men and women. Appl Physiol Nutr Metab. 2016 Nov;41(11):1117-1123. doi: 10.1139/apnm-2016-0253. Epub 2016 Jul 7.

    PMID: 27753506BACKGROUND

  • Bahey El-Deen HA, Atef H, Munoz-Gomez E, Moreno-Segura N, ElZalabany S, Alanazi R, Alruwili W, Alruwili S, Sultan S, Marques-Sule E. Effects of reduced-exertion high-intensity training versus short moderate-intensity continuous training on biomarkers of mortality risk in sedentary women: A randomized clinical trial. J Bodyw Mov Ther. 2025 Jun;42:710-714. doi: 10.1016/j.jbmt.2025.01.056. Epub 2025 Feb 2.

    PMID: 40325745DERIVED

MeSH Terms

Conditions

Sedentary Behavior

Condition Hierarchy (Ancestors)

Behavior

Study Officials

  • Elena Marqués Sulé, PhD

    Univeristy of Valencia

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Masking Details
The outcomes assessor will be blinded to treatment group allocation. The blinded assessor will collect all baseline and post-intervention measures and enter data.
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

May 16, 2023

First Posted

May 25, 2023

Study Start

December 1, 2021

Primary Completion

April 30, 2022

Study Completion

April 30, 2022

Last Updated

May 25, 2023

Record last verified: 2023-05

Data Sharing

IPD Sharing
Will not share

Locations

ES(1)