Evaluating the Episodic Future Thinking Intervention for Reducing Cigarette Consumption in Cigarette Smokers

NCT05825001 | Active Not Recruiting

• 1 other identifier: I 2684022
• Study Type: interventional
• Target: 104
• Locations: 1 country
• Sites: 1

Brief Summary

This clinical trial evaluates the effectiveness of active episodic future thinking (EFT) stimuli for reducing cigarette consumption in cigarette smokers. EFT is an innovative framing method shown to significantly activate brain regions involved in future thinking, planning, and other executive functions. Active EFT stimuli are positive events, unrelated to smoking, that participants anticipate, look forward to, and can vividly imagine happening up to 1 year in the future. Control EFT stimuli are positive past events, unrelated to smoking, that participants can vividly remember happening in the recent past. Active EFT stimuli may help reduce cigarette consumption among cigarette smokers by exposing them to personally relevant future oriented stimuli.

Conditions

Cigarette Smoking-Related Carcinoma

Outcome Measures

Primary Outcomes (1)

• Concentration of carbon monoxide on breath

  Will be measured by Micro+Basic carbon monoxide monitor

  From baseline up to 30 days

Secondary Outcomes (1)

• Reduction in delay discounting rate

  Up to 30 days

Study Arms (2)

Arm 1 (active EFT)

EXPERIMENTAL

Participants receive the active EFT stimulus and use the iCOquit Smokerlyzer carbon monoxide monitor on study.

Behavioral: Smoking Cessation Intervention; Other: Medical Device Usage and Evaluation

Arm II (control EFT)

ACTIVE COMPARATOR

Participants receive the control EFT stimulus and use the iCOquit Smokerlyzer carbon monoxide monitor on study.

Behavioral: Smoking Cessation Intervention (control); Other: Medical Device Usage and Evaluation

Interventions

Smoking Cessation Intervention BEHAVIORAL

Receive active EFT stimulus

Also known as: Smoking and Tobacco Use Cessation Interventions

Arm 1 (active EFT)

Smoking Cessation Intervention (control) BEHAVIORAL

Receive control EFT stimulus

Also known as: Smoking and Tobacco Use Cessation Interventions

Arm II (control EFT)

Medical Device Usage and Evaluation OTHER

Use iCOquit Smokerlyzer carbon monoxide monitor

Arm 1 (active EFT); Arm II (control EFT)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Smoke \>= 10 cigarettes daily
• \>32 on the Vividness of Visual Imagery Questionnaire (VVIQ)
• No regular use of other tobacco products
• In possession of a smartphone with text messaging capabilities
• Willing to quit smoking in the next 30 days
• Low socioeconomic status
• Veteran of the US armed services

You may not qualify if:

• Unable or unwilling to provide verbal consent
• Unable or unwilling to provide data to the research team
• Current use of nicotine replacement therapy, bupropion, or varenicline
• Use of drugs of abuse in the past 30 days
• Living in the same household as a participant already enrolled in this study
• Unable or unwilling to use nicotine patches

Sponsors & Collaborators

• Roswell Park Cancer Institute: lead

Study Sites (1)

Roswell Park Comprehensive Cancer Center

Buffalo, New York, 14263, United States

Location

MeSH Terms

Interventions

Smoking Devices

Intervention Hierarchy (Ancestors)

Manufactured Materials; Technology, Industry, and Agriculture

Study Officials

• Christine Sheffer

  Roswell Park

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 11, 2023
• First Posted: April 24, 2023
• Study Start: September 15, 2024
• Primary Completion: October 1, 2025
• Study Completion (Estimated): October 1, 2026
• Last Updated: February 5, 2026

Record last verified: 2026-02

Locations

US (1)