NCT05786482

Brief Summary

Chronic physical conditions are defined as conditions that require ongoing management and treatment over extended periods of time. Chronic physical conditions are not only leading causes of death and disability in North America but they are commonly associated with mental distress and reduced quality of life. Online mind-body wellness programming ranging from physical activity to mindfulness interventions has been shown to be effective in improving mental wellness in a variety of chronic disease populations, but there is a need to evaluate scalable ways to deliver these programs. Building upon a previously developed online wellness program for inflammatory bowel disease (IBD) and primary biliary cholangitis (PBC), the research team has developed a mind-body wellness program for adults ≥18 years of age living with different chronic conditions (e.g., cirrhosis, PBC, heart failure). The 12-week program will be delivered online, and include follow- along mindful movement, breathwork and meditation routines, and a psychology based coping skills program. In a three-armed randomized controlled trial, the study will assess the impact on the primary outcome of anxiety and depression as measured through the hospital anxiety and depression scale (HADS). At the beginning and the end of the 12-week research study, participants will complete surveys to assess secondary/exploratory outcome measures including quality of life, fatigue, frailty, demoralization, and healthcare usage. After the program, the research team will conduct interviews with participants to allow them to share their other feedback about the program. The researchers will also send surveys to the participants eight weeks after the program ends to assess longer- term impacts on primary and secondary outcomes.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
825

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Feb 2023

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 12, 2023

Completed
25 days until next milestone

First Submitted

Initial submission to the registry

March 9, 2023

Completed
18 days until next milestone

First Posted

Study publicly available on registry

March 27, 2023

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 22, 2024

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2024

Completed
Last Updated

January 6, 2025

Status Verified

January 1, 2025

Enrollment Period

1.6 years

First QC Date

March 9, 2023

Last Update Submit

January 3, 2025

Conditions

Keywords

Mind Body WellnessDepressionAnxietyQuality of LifeWellbeingYogaMeditationPsychology

Outcome Measures

Primary Outcomes (1)

  • Hospital Anxiety and Depression Scale (HADS)

    Depression and anxiety will be measured on the Hospital Anxiety and Depression Scale. The minimum value is 0, the maximum is 21, and higher scores mean a worse outcome.

    12 weeks

Secondary Outcomes (5)

  • Modified Fatigue Impact Scale (MFIS)

    12 weeks

  • Health Related Quality of Life

    12 weeks

  • EQ-5D-5L

    12 weeks

  • Capability, Opportunity, Motivation, Behaviour (COM-B) Survey

    12 weeks

  • Satisfaction and Adherence

    12 weeks

Other Outcomes (5)

  • Demoralization (Exploratory)

    12 weeks

  • Edmonton Frail Scale (Exploratory)

    12 weeks

  • Fried Frailty (Exploratory)

    12 weeks

  • +2 more other outcomes

Study Arms (3)

Waitlist Control

NO INTERVENTION

Online Program

EXPERIMENTAL

Online program (mindful movement, meditation, breathwork, psychology-based coping skills program)

Behavioral: Online mind-body wellness program

Online Program + Weekly Check-ins

EXPERIMENTAL

Online program (mindful movement, meditation, breathwork, psychology-based coping skills program) + brief 1-to-1 weekly check-ins with a study team member

Behavioral: Online mind-body wellness program + Weekly Check-ins

Interventions

Online program (mindful movement, meditation, breathwork, psychology-based coping skills program)

Online Program

Online program (mindful movement, meditation, breathwork, psychology-based coping skills program) + brief weekly check-ins

Online Program + Weekly Check-ins

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Adults ≥18 years of age
  • Identified diagnosis of one of nine chronic conditions (Heart Failure, PBC, Digestive Disease, Cirrhosis, Cancer survivor, Post-transplant, Women who have experienced a cardiac event, Chronic Kidney Disease), or another general category for physical chronic conditions not captured by these nine
  • English language proficiency to complete questionnaires and read the educational material
  • Access to the Internet and a computer or smart device at home

You may not qualify if:

  • Receiving compassionate care
  • Inability to provide informed written consent
  • Severe psychiatric disorders (presence of uncontrolled schizophrenia, post-traumatic stress disorder (PTSD), and/or bipolar disorder unless approved to participate by their physician/psychologist; suicidality nearly every day)
  • No access to the internet

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Alberta

Edmonton, Alberta, T6G2X8, Canada

Location

Related Publications (1)

  • Tiles-Sar N, Neuser J, de Sordi D, Baltes A, Preiss JC, Moser G, Timmer A. Psychological interventions for treatment of inflammatory bowel disease. Cochrane Database Syst Rev. 2025 Apr 17;4(4):CD006913. doi: 10.1002/14651858.CD006913.pub3.

MeSH Terms

Conditions

Liver Cirrhosis, BiliaryHeart FailureDigestive System DiseasesLiver CirrhosisNeoplasmsRenal Insufficiency, ChronicDepressionAnxiety Disorders

Condition Hierarchy (Ancestors)

Cholestasis, IntrahepaticCholestasisBile Duct DiseasesBiliary Tract DiseasesLiver DiseasesFibrosisPathologic ProcessesPathological Conditions, Signs and SymptomsHeart DiseasesCardiovascular DiseasesRenal InsufficiencyKidney DiseasesUrologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital DiseasesChronic DiseaseDisease AttributesBehavioral SymptomsBehaviorMental Disorders

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 9, 2023

First Posted

March 27, 2023

Study Start

February 12, 2023

Primary Completion

September 22, 2024

Study Completion

December 1, 2024

Last Updated

January 6, 2025

Record last verified: 2025-01

Locations