Short, Simple, Exercise to Improve Circadian Dependent Postprandial Glycemic Responses

NCT05783752 | Completed

• 1 other identifier: HS-2023-0003
• Study Type: interventional
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to test whether one minute of stair stepping at a comfortable pace can reduce blood sugar after meals. The main objectives of the study are: Compare continuously measured post-meal glucose after stair-stepping to control condition Compare continuously measured post-meal glucose after stair-stepping between meals Assess interaction between condition and meal to determine if the effect of stair-stepping on post-meal glucose depends on meal Participants will be in the study for 10 days and will be asked to: Wear a continuous glucose monitor over the course of the study Perform either one minute of comfortable pace stair stepping 15 min after each meal OR no exercise 1 hour after eating a meal on alternating days Perform a dietary recall every two days Perform no exercise within one hour after each meal on any day during the study Consume no calories within one hour after each meal during the study

Conditions

Postprandial Glycemic Response; Postprandial Hyperglycemia; Postprandial Insulin

Outcome Measures

Primary Outcomes (1)

• Postprandial Blood Glucose

  mg/dL

  continuous measure from meal consumption up to 1 hour post meal

Study Arms (2)

Stair-Stepping then Control

EXPERIMENTAL

Participants start with stair-stepping 15 minutes after meals on day 1 followed by no exercise on day 2. Sequence continues throughout the 10 days.

Behavioral: Stair Stepping; Behavioral: No exercise control

Control then Stair-Stepping

EXPERIMENTAL

Participants start with no exercise on day 1 followed by stair-stepping 15 minutes after meals on day 2. Sequence continues throughout the 10 days.

Behavioral: Stair Stepping; Behavioral: No exercise control

Interventions

Stair Stepping BEHAVIORAL

1 minute of stair-stepping (30 seconds up, 30 seconds down) at a self-selected pace identified on day 0 starting 15 minutes after each meal

Control then Stair-Stepping; Stair-Stepping then Control

No exercise control BEHAVIORAL

Participants avoid exercise within 1 hour of eating a meal

Control then Stair-Stepping; Stair-Stepping then Control

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• between 18 and 65 years
• able to climb and descend stairs
• access to stairs

You may not qualify if:

• glycemic medications that vary in dosage
• dosage from meal to meal or day to day (eg insulin titrated to meal size or carbohydrate content)

Sponsors & Collaborators

• San Diego State University: lead

Study Sites (1)

San Diego State University

San Diego, California, 92182, United States

Location

MeSH Terms

Conditions

Hyperglycemia

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 13, 2023
• First Posted: March 24, 2023
• Study Start: February 20, 2023
• Primary Completion: August 7, 2023
• Study Completion: August 14, 2023
• Last Updated: July 14, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)