Trials Sponsors Conditions Drugs Pricing

Conditions

Brain Metastases Carcinoma, Non-Small-Cell Lung

Outcome Measures

Primary Outcomes (1)

overall survival (OS)
OS is defined as the time elapsed between the initiation of radiotherapy and mortality from any cause.
February 13, 2023-February 13, 2024

Secondary Outcomes (2)

progression-free survival (PFS)
February 13, 2023-February 13, 2024
intracranial PFS (iPFS)
February 13, 2023-February 13, 2024

Study Arms (1)

Observation group

This is an observational study, no interventions will be applied to patients in the observation group, and only blood and cerebrospinal fluid ctDNA and TCR data of patients with brain metastases from non-small cell lung cancer treated with radiotherapy will be recorded to predict patient prognosis. Peripheral blood and CSF samples were collected at baseline, 24 h (T0), and 28 days (T28) after completion of radiotherapy and underwent deep sequencing of ctDNA and TCR. The 6-month response rates of brain metastases and systemic lesions were evaluated based on Response Evaluation Criteria in Solid Tumors version 1.1 for further study.

Radiation: Whole-brain radiotherapy

Interventions

Whole-brain radiotherapyRadiation

Radiotherapy is administered to the patient's brain lesions, and the subject's specific treatment plan is developed by two specialized physicians.

Also known as: Stereotactic radiotherapy

Observation group

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years - 80 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodProbability Sample

Study Population

A group of non-small cell lung cancer patients with brain metastasis who have never received radiotherapy

You may qualify if:

Age \> 18 years

Sponsors & Collaborators

Xiaorong Dong
Otherlead

Study Sites (1)

Union hospital

Wuhan, Hubei, 430000, China

MeSH Terms

Conditions

Carcinoma, Non-Small-Cell LungBrain Neoplasms

Interventions

Radiosurgery

Condition Hierarchy (Ancestors)

Carcinoma, BronchogenicBronchial NeoplasmsLung NeoplasmsRespiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by SiteNeoplasmsLung DiseasesRespiratory Tract DiseasesCentral Nervous System NeoplasmsNervous System Neoplasms

Study Officials

Xiaorong Dong, Dr.
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
STUDY CHAIR

Central Study Contacts

Xiaorong Dong, Dr.

CONTACT

13986252286 xiaorongdong@hust.edu.cn

Study Design

Study Type: observational
Observational Model: COHORT
Time Perspective: RETROSPECTIVE
Sponsor Type: OTHER
Responsible Party: SPONSOR INVESTIGATOR
PI Title: Professor/Chief Physician

Study Record Dates

First Submitted

February 12, 2023

First Posted

February 21, 2023

Study Start

February 13, 2023

Estimated (date passed)

This estimate has passed. The registry has not confirmed an actual date for this milestone.

Primary Completion

February 13, 2024

Circulating Tumor DNA and T Cell Repertoire Predict Radiotherapeutic Outcomes in NSCLC Patients With Brain Metastasis

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

Study Start

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (2)

Study Arms (1)

Observation group

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Intervention Hierarchy (Ancestors)

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

Study Start

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (2)

Study Arms (1)

Observation group

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Interventions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Intervention Hierarchy (Ancestors)

Data Sharing

Source record

Locations