Brain Metastases
347
78
109
94
Key Insights
Highlights
Success Rate
72% trial completion
Published Results
38 trials with published results (11%)
Research Maturity
94 completed trials (27% of total)
Clinical Risk Assessment
Based on trial outcomes
High Risk
Score: 59/100
10.4%
36 terminated out of 347 trials
72.3%
-14.3% vs benchmark
7%
24 trials in Phase 3/4
40%
38 of 94 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.6%
Based on 94 completed trials
Clinical Trials (347)
Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases
Hippocampal Sparing Whole Brain Radiation Versus Stereotactic Radiation in Patients With 5-20 Brain Metastases: A Phase III, Randomized Trial
Stereotactic Radiation in Patients With Small Cell Lung Cancer and 1-10 Brain Metastases
SRS & Abemaciclib w/wo Imlunestrant in the Management of HR+/HER2- Breast CA Brain Metastases
A Pilot Study to Assess the Clinical Utility of 18F-Fluciclovine (Axumin) PET-CT for Detecting True-versus Pseudo-Progression of Brain Metastases on Immunotherapy
Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial)
Feasibility of 18F-Fluciclovine PET/CT to Identify Brain Metastasis
Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR BeaM)
A Phase II Study of Nivolumab With Ipilimumab and Cabozantinib in Patients With Untreated Renal Cell Carcinoma Brain Metastases
Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)
Neurocognitive Decline in Patients With Brain Metastases
Preoperative Embolization for Highly Vascular Brain Tumors
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
Development of MRF for Characterization of Brain Tumors After Radiotherapy
Frameless Stereotactic Radiosurgery for Intact Brain Metastases
CBF and NCF Changes With Brain Radiation
Repotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain Metastasis
Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases
IL-8 Receptor Modified Patient-Derived Activated CD70 CAR T Cell Therapy in Adults With Brain Metastases
Diffusion-weighted MRI to Predict Treatment Response in Stereotactic Radiotherapy of Central Nervous System (CNS) Metastases