Key Insights

Highlights

Success Rate

72% trial completion

Published Results

198 trials with published results (28%)

Research Maturity

320 completed trials (46% of total)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 49/100

Termination Rate

18.1%

126 terminated out of 697 trials

Success Rate

71.7%

-14.8% vs benchmark

Late-Stage Pipeline

15%

108 trials in Phase 3/4

Results Transparency

62%

198 of 320 completed with results

Key Signals

198 with results72% success126 terminated

Data Visualizations

Phase Distribution

579Total
Not Applicable (41)
Early P 1 (4)
P 1 (179)
P 2 (247)
P 3 (92)
P 4 (16)

Trial Status

Completed320
Terminated126
Unknown98
Recruiting62
Active Not Recruiting56
Withdrawn18

Trial Success Rate

71.7%

Benchmark: 86.5%

Based on 320 completed trials

Clinical Trials (697)

Showing 20 of 20 trials
NCT02905591Phase 2Active Not RecruitingPrimary

A Phase 2 Study Adding Ascorbate to Chemotherapy and Radiation Therapy for NSCLC

NCT06532032Phase 1CompletedPrimary

A Study of Combination Therapy With Amivantamab and Docetaxel in Participants With Metastatic Non-small Cell Lung Cancer

NCT05642195Phase 1Suspended

Evaluation of a Cancer Lysate Vaccine and Montanide (Registered Trademark) ISA-51 VG With or Without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung Cancer

NCT05488314Phase 1Active Not RecruitingPrimary

A Study of Amivantamab and Capmatinib Combination Therapy in Unresectable Metastatic Non-small Cell Lung Cancer

NCT07586202Phase 2RecruitingPrimary

A Study of Neoadjuvant Amivantamab With Either Lazertinib or Chemotherapy in Participants With Resectable EGFR-Mutated NSCLC

NCT07227025Phase 1RecruitingPrimary

A Study of Amivantamab and Olomorasib Combination Therapy in Participants With Metastatic Non-Small Cell Lung Cancer

NCT07230691RecruitingPrimary

A Study of Clinical Outcomes in Participants With EGFR Mutated Advanced Non-Small Cell Lung Cancer (NSCLC) in a Real-World Setting

NCT05663866Phase 2Active Not RecruitingPrimary

Premedication to Reduce Amivantamab Associated Infusion Related Reactions

NCT06120140Phase 2Active Not RecruitingPrimary

Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib

NCT06667076Phase 2RecruitingPrimary

A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

NCT06623422Phase 3RecruitingPrimary

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

NCT04165798RecruitingPrimary

KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)

NCT04165070Phase 1RecruitingPrimary

KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)

NCT04988295Phase 3Active Not RecruitingPrimary

A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure

NCT07339176Phase 1Recruiting

Intratumoral N17350 in Advanced Solid Tumors

NCT07373899Enrolling By InvitationPrimary

Comparison of the Effect of Surgical Resection Based on Lesion Extent Before and After Neoadjuvant Therapy in Patients With Stage II-IIIB Non-Small Cell Lung Cancer: A Single-Center, Real-World, Open-Label Study

NCT06012435Phase 3Active Not RecruitingPrimary

A Study of SGN-B6A Versus Docetaxel in Previously Treated Non-small Cell Lung Cancer

NCT06003231Phase 2Active Not RecruitingPrimary

A Study of Disitamab Vedotin in Previously Treated Solid Tumors That Express HER2

NCT06875310Phase 3RecruitingPrimary

A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

NCT05208762Phase 1RecruitingPrimary

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

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