Key Insights

Highlights

Success Rate

72% trial completion

Published Results

193 trials with published results (28%)

Research Maturity

316 completed trials (46% of total)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 49/100

Termination Rate

17.3%

120 terminated out of 693 trials

Success Rate

72.5%

-14.0% vs benchmark

Late-Stage Pipeline

16%

108 trials in Phase 3/4

Results Transparency

61%

193 of 316 completed with results

Key Signals

193 with results72% success120 terminated

Data Visualizations

Phase Distribution

577Total
Not Applicable (40)
Early P 1 (4)
P 1 (179)
P 2 (246)
P 3 (92)
P 4 (16)

Trial Status

Completed316
Terminated120
Unknown99
Recruiting65
Active Not Recruiting59
Withdrawn18

Trial Success Rate

72.5%

Benchmark: 86.5%

Based on 316 completed trials

Clinical Trials (693)

Showing 20 of 20 trials
NCT05642195Phase 1Suspended

Evaluation of a Cancer Lysate Vaccine and Montanide (Registered Trademark) ISA-51 VG With or Without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung Cancer

NCT05983133Phase 1Terminated

A Study of PF-08046052/SGN-EGFRd2 in Advanced Solid Tumors

NCT06862869RecruitingPrimary

Real World Clinical Outcomes of Resected ALK-Positive Early Stage NSCLC Patients Treated With Alectinib as Adjuvant Therapy

NCT03456076Phase 3Active Not RecruitingPrimary

A Study Comparing Adjuvant Alectinib Versus Adjuvant Platinum-Based Chemotherapy in Patients With ALK Positive Non-Small Cell Lung Cancer

NCT06623422Phase 3RecruitingPrimary

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

NCT05456256Phase 2Recruiting

A Study of LP-300 With Carboplatin and Pemetrexed in Never Smokers With Advanced Lung Adenocarcinoma

NCT06780085Phase 2RecruitingPrimary

A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01)

NCT06855771Phase 2RecruitingPrimary

A Study of BMS-986504 in Participants With Pre-treated Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) With Homozygous MTAP Deletion (MountainTAP-9)

NCT06431633Phase 3Recruiting

Study of Treatment With Sacituzumab and Zimberelimab for Patients With Lung Cancer Confined to the Chest and Previously Operated on Who Were Not Disease-free.

NCT03586453Phase 2Active Not RecruitingPrimary

Osimertinib In EGFR Mutant Lung Cancer

NCT06875310Phase 3RecruitingPrimary

A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

NCT03833154Phase 3Active Not RecruitingPrimary

Durvalumab With Stereotactic Body Radiation Therapy (SBRT) vs Placebo With SBRT in Early Stage Unresected Non-small Cell Lung Cancer (NSCLC) Patients/ Osimertinib Following SBRT in Patients With Early Stage Unresected NSCLC Harboring an EGFR Mutation

NCT04487080Phase 3Active Not RecruitingPrimary

A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer

NCT04988295Phase 3Active Not RecruitingPrimary

A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure

NCT06623656Phase 2RecruitingPrimary

Preoperative Radioimmunotherapy Versus Chemoimmunotherapy in NSCLC

NCT03485209Phase 2Active Not Recruiting

Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors

NCT06758401Phase 3Recruiting

This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

NCT06447662Phase 1Recruiting

A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.

NCT07222566Phase 3Recruiting

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

NCT06119581Phase 3RecruitingPrimary

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

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