Satiety of High-Protein Ramen Noodles

NCT05725681 | Completed

• 1 other identifier: 22-0729
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to determine if high-protein instant ramen noodles acutely increase satiety, reduce hunger, and improve blood sugar levels compared to standard instant ramen noodles in generally healthy young to middle aged adults. In addition, investigators aim to test if intake of high-protein instant ramen noodles reduces caloric intake at the next meal compared to standard instant ramen noodles.

Conditions

Appetitive Behavior

Outcome Measures

Primary Outcomes (1)

• Appetite Score Area Under the Curve (mm*180 minutes)

  Calculated as satiety + fullness + (100 - hunger) + (100 - prospective food consumption)/4. Questions 1-4 from the Visual Analogue Scale will be used to assess satiety, fullness, hunger and prospective food consumption and calculate the Appetite Score

  0 to 180 minutes

Secondary Outcomes (28)

• Ghrelin Area Under the Curve (pg/mL*180 minutes)

  0 to 180 minutes

• Glucagon like peptide-1 (GLP-1) Area Under the Curve (pg/mL*180 minutes)

  0 to 180 minutes

• Peptide-YY (PYY) Area Under the Curve (pg/mL*180 minutes)

  0 to 180 minutes

• Glucose Area Under the Curve (mg/dL*180 minutes)

  0 to 180 minutes

• Insulin Area Under the Curve (mUI*180 minutes)

  0 to 180 minutes

Study Arms (2)

High protein ramen

EXPERIMENTAL

Participants will be asked to limit physical activity to a specified level, consume a standardized meal at night and report to the clinic after a 12 h overnight fast. At our clinic, for this arm, participants will consume one portion of high-protein instant ramen noodles (71 g; Chef Woo, Borealis Foods). In the 4-hours following the ramen breakfast, blood will be sampled at regular intervals (0 minutes - before starting the breakfast, and 30, 60, 120 and 180 minutes after stopping breakfast) for hunger and satiety hormones (i.e., glucagon like peptide-1, peptide-YY, and ghrelin), and glucose and insulin. Visual Analogue Scales will also be administered to assess subjective hunger and satiety. At 4-hours, a buffet-style lunch will be provided and caloric intake at the meal will be covertly assessed.

Other: High protein ramen

Standard ramen

ACTIVE COMPARATOR

Participants will be asked to limit physical activity to a specified level, consume a standardized meal at night and report to the clinic after a 12 h overnight fast. At our clinic, for this arm, participants will consume an isocaloric, weight matched portion of standard instant ramen noodles. In the 4-hours following the ramen breakfast, blood will be sampled at regular intervals (0 minutes - before starting the breakfast, and 30, 60, 120 and 180 minutes after stopping breakfast) for hunger and satiety hormones (i.e., glucagon like peptide-1, peptide-YY, and ghrelin), and glucose and insulin. Visual Analogue Scales will also be administered to assess subjective hunger and satiety. At 4-hours, a buffet-style lunch will be provided and caloric intake at the meal will be covertly assessed.

Other: Standard ramen

Interventions

High protein ramen OTHER

Participants will be served one portion of high-protein instant ramen noodles \[CHEF WOO Roasted Chicken Flavor Ramen Cup Noodles, Borealis Foods; 71 g\]

High protein ramen

Standard ramen OTHER

Participants will be served one portion of standard instant ramen noodles \[RAMEN EXPRESS Chicken Flavor Ramen Cup Noodle Chef Woo, Borealis Foods; 71 g\]

Standard ramen

Eligibility Criteria

• Age: 25 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Body Mass Index 20-30 kg/m2

You may not qualify if:

• Unwilling or unable to have an IV catheter inserted
• Body weight \<110 pounds
• Diabetes (any type)
• Fasting capillary glucose ≥100 mg/dL
• Unstable systemic medical condition
• \>10% change in body weight in the prior 3 months
• Medications that affect appetite or glucose regulation
• Prior bariatric surgery
• Uncontrolled hypertension (i.e., unmedicated blood pressure \>130/90 mmHg)
• Intolerance, dislike or allergy to the study food
• Current or recent (within 6 months) tobacco use
• High alcohol consumption (\>14 drinks/week)
• Currently following a weight loss diet
• Irregular menstrual cycle
• Currently pregnant or lactating

Sponsors & Collaborators

• Texas Tech University: lead

Study Sites (1)

Nutrition and Metabolic Health Initiative

Lubbock, Texas, 79409, United States

Location

MeSH Terms

Conditions

Appetitive Behavior

Condition Hierarchy (Ancestors)

Behavior, Animal; Behavior

Study Officials

• Nikhil Dhurandhar

  Department of Nutritional Sciences Texas Tech University

  PRINCIPAL INVESTIGATOR

• Kristina Petersen

  Department of Nutritional Sciences Texas Tech University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 3, 2023
• First Posted: February 13, 2023
• Study Start: June 1, 2023
• Primary Completion: December 2, 2023
• Study Completion: December 2, 2023
• Last Updated: April 23, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ANALYTIC CODE

Locations

US (1)