Effect of Oral Lactate Ingestion on Appetite Regulation

NCT06379815 | Not Yet Recruiting

• 1 other identifier: EMRL-23-03
• Study Type: interventional
• Target: 12
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal if this study is to determine how oral lactate ingestion affects markers of appetite regulation. Researchers will compare oral lactate ingestion to a sodium chloride placebo. Participants will consume the lactate or placebo solution and then have blood samples and assessments of appetite over the course of 90 min. Free-living energy intake will be measured for 3 days surrounding each experimental session.

Conditions

Appetitive Behavior

Keywords

lactate; appetite regulation; acylated ghrelin; energy intake

Outcome Measures

Primary Outcomes (3)

• Blood Lactate

  Lactate measured in blood.

  Pre-ingestion, 30 minutes following ingestion, 45 minutes following ingestion, 60 minutes following ingestion, and 90minutes following ingestion.

• Acylated ghrelin

  Acylated ghrelin measured in blood via ELISA.

  Pre-ingestion, 30 minutes following ingestion, 45 minutes following ingestion, 60 minutes following ingestion, and 90minutes following ingestion.

• Total ghrelin

  Total ghrelin measured in blood via ELISA.

  Pre-ingestion, 30 minutes following ingestion, 45 minutes following ingestion, 60 minutes following ingestion, and 90minutes following ingestion.

Secondary Outcomes (2)

• Subjective appetite perception

  Pre-ingestion, 30 minutes following ingestion, 45 minutes following ingestion, 60 minutes following ingestion, and 90minutes following ingestion.

• Free-living energy intake

  Day 1 (day before the experimental session), Day 2 (day of the experimental session), and Day 3 (day after the experimental session).

Study Arms (2)

Sodium Lactate

EXPERIMENTAL

Participants will received 0.45 g/kg of sodium lactate (SO179, Spectrum Chemical MFG Group) mixed with water. This will be mixed at a ratio of 30 mL per g of lactate. Lemon juice is added to the mixture at a specific ratio to balance the pH of the solution. Crystal light will also be added to avoid any taste differences between beverages.

Other: Sodium Lactate

Sodium Chloride

PLACEBO COMPARATOR

Participants will receive a equimolar amount of sodium chloride (S9888, MilliporeSigma) mixed with water. The amount of water, lemon juice, and crystal light will be matched to that of the sodium lactate condition.

Other: Sodium Chloride

Interventions

Sodium Lactate OTHER

See arm/group description.

Sodium Lactate

Sodium Chloride OTHER

See arm/group description.

Sodium Chloride

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Deemed healthy using Canadian Society for Exercise Physiology Get Active Questionnaire
• Female participants must be eumenorrheic (menstrual cycle length between 21-35 days)

You may not qualify if:

• Taking supplements or medications known to affect metabolism (e.g., creatine, beta-blockers)
• Currently pregnant or a pregnancy of \>3 months within the last 3 years,

Sponsors & Collaborators

• Wilfrid Laurier University: lead
• Natural Sciences and Engineering Research Council, Canada: collaborator

MeSH Terms

Conditions

Appetitive Behavior

Interventions

Sodium Lactate; Sodium Chloride

Condition Hierarchy (Ancestors)

Behavior, Animal; Behavior

Intervention Hierarchy (Ancestors)

Lactates; Hydroxy Acids; Carboxylic Acids; Organic Chemicals; Chlorides; Hydrochloric Acid; Chlorine Compounds; Inorganic Chemicals; Sodium Compounds

Study Officials

• Tom J Hazell, PhD

  Wilfrid Laurier University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Tom J Hazell, PhD

CONTACT

5488893902; thazell@wlu.ca

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: The allocation of lactate and placebo will be completed by a researcher not involved in data collection. Both the participant and the researchers collecting and analyzing the data will be blinded to the treatment allocation. This will be completed in a counter-balanced order.
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Model Details: Participants will consume a sodium lactate and sodium chloride placebo in a double-blind, crossover design.

Study Record Dates

• First Submitted: April 12, 2024
• First Posted: April 23, 2024
• Study Start: May 1, 2024
• Primary Completion: August 1, 2024
• Study Completion: August 1, 2024
• Last Updated: April 23, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share