Familial B-cell Lymphoproliferative Disorders
Familial_LPD
Epidemiology of Familial B-cell Lymphoproliferative Disorders
1 other identifier
observational
1,000
0 countries
N/A
Brief Summary
This study investigates families with at least two cases of B-cell lymphoproliferative disorders (LPD), and evaluates the prevalence of LPD in families, the relationship between medical history, genetic factors, and the risk of familial LPD, and various clinical outcomes for these families in a multiethnic population of Jews and Arabs in Israel.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2024
Longer than P75 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 30, 2023
CompletedFirst Posted
Study publicly available on registry
February 8, 2023
CompletedStudy Start
First participant enrolled
June 1, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 1, 2040
May 8, 2024
May 1, 2024
4.5 years
January 30, 2023
May 7, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Prevalence of familial LPD in Israel
5 years
Association between medical history and genetic variants and the risk of familial LPD
5 years
Risk of clinical outcomes among familial LPD and family members
15 years
Study Arms (15)
Bnai Zion Medical Center
Bnai Zion Medical Center
Tel Aviv Sourasky Medical Center - Ichilov Hospital
Tel Aviv Sourasky Medical Center - Ichilov Hospital
Galil Medical Center
Galil Medical Center
Ziv Medical Center
Ziv Medical Center
Emek Medical Center
Emek Medical Center
Beilinson Hospital
Beilinson Hospital
Meir Medical Center
Meir Medical Center
Kaplan Medical Center
Kaplan Medical Center
Sheba Medical Center
Sheba Medical Center
Rambam Medical Center
Rambam Medical Center
Shaare Zdek Medical Center
Shaare Zdek Medical Center
Hadassah Medical Center
Hadassah Medical Center
Shamir Medical Center (Assaf Harofeh)
Shamir Medical Center (Assaf Harofeh)
Soroka Medical Center
Soroka Medical Center
Assuta Ashdod Hospital
Assuta Ashdod Hospital
Interventions
No intervention
Eligibility Criteria
Jewish and Arab LPD families with at least 2 family members with LPD.
You may qualify if:
- Patients must have LPD and must have a family history of LPD. LPD patients who signed an informed consent to participate in the study.
- Relatives must be related by blood to LPD patients or unrelated (for control group).
- Relatives who signed an informed consent to participate in the study.
You may not qualify if:
- Pregnant women, special populations and those lacking judgment will not be included
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Haifalead
- Bnai Zion Medical Centercollaborator
Biospecimen
Blood and saliva samples
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Geffen Kleinstern, PhD
University of Haifa
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- FAMILY BASED
- Time Perspective
- OTHER
- Target Duration
- 15 Years
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Senior Lecturer
Study Record Dates
First Submitted
January 30, 2023
First Posted
February 8, 2023
Study Start
June 1, 2024
Primary Completion (Estimated)
December 1, 2028
Study Completion (Estimated)
December 1, 2040
Last Updated
May 8, 2024
Record last verified: 2024-05
Data Sharing
- IPD Sharing
- Will not share