Study on the Relationship Between Iodine Nutrition and Thyroid Diseases in the Elderly

NCT05716191 | Unknown DMC

• 1 other identifier: NSFC-82204041
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 3

Brief Summary

The aging trend of China's population is intensifying. More than 50% of the elderly in China suffer from thyroid disease. Thyroid dysfunction in the elderly increases the risk of cardiovascular and metabolic diseases. Even if thyroid-stimulating hormone (TSH) is within the normal range, brain atrophy and infarction-like vascular damage in elderly males will be aggravated with the increased TSH level. Iodine is an essential component of thyroid hormones. Iodine deficiency or excess may lead to a series of thyroid diseases. The risk threshold of iodine intake in the elderly is unknown. The goal of this observational study is to clarify the relationship between thyroid diseases and iodine intake in the elderly. The aims are:

1. 1.to clarify the differences in the prevalence of thyroid diseases in the elderly with different iodine nutrition backgrounds.
2. 2.to analyze the effects of mild iodine deficiency and iodine excess on the thyroid health of the elderly.
3. 3.to explore the hazard threshold of iodine intake for old people.
4. 4.to compare the differences in thyroid disease and iodine nutritional status between young and middle-aged people and old people.

Conditions

Nutrition, Healthy; Elderly

Keywords

iodine; thyroid diseases; adults

Outcome Measures

Primary Outcomes (6)

• thyroid function Indicators

  Blood samples were collected to evaluate thyroid function.

  2 years

• thyroid volume

  Thyroid volume was measured by B-ultrasound.

  2 years

• thyroid nodules

  thyroid nodules were measured by B-ultrasound.

  2 years

• concentration of urinary iodine

  The midstream urine samples were collected.

  2 years

• concentration of salivary iodine

  The salivary samples were collected.

  2 years

• dietary iodine intake

  Dietary iodine was measured by idine dietary frequency questionnaire.

  2 years

Secondary Outcomes (5)

• free triiodothyronine (FT3)

  2 years

• free thyroxine (FT4)

  2 years

• thyroid-stimulating hormone (TSH)

  2 years

• thyroperoxidase antibody (TPOAb)

  2 years

• thyroglobulin antibody (TGAb)

  2 years

Interventions

Naturally different iodine levels exposure OTHER

A cross-sectional survey of thyroid disease in elderly people in areas with different iodine nutrition backgrounds

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Elderly people with different levels of iodine exposure.

You may qualify if:

• \. adults with at least 5 years of local residence;

You may not qualify if:

• adults with family genetic diseases
• adults with special dietary habits
• adults taking iodine-containing drugs or supplements
• adults with protein or nutritional deficiencies

Sponsors & Collaborators

• Tianjin Medical University: lead
• Tianjin Medical University General Hospital: collaborator
• Shandong Provincial Institute for Endemic Disease Control: collaborator

Study Sites (3)

Gansu provincial center for disease control and prevention

Lanzhou, Gansu, 730099, China

RECRUITING

Shandong provincial institute for endemic disease control

Jinan, Shandong, 250014, China

RECRUITING

Tianjin Medical University

Tianjin, Tianjin Municipality, 300070, China

ACTIVE NOT RECRUITING

Related Publications (10)

• Zimmermann MB, Boelaert K. Iodine deficiency and thyroid disorders. Lancet Diabetes Endocrinol. 2015 Apr;3(4):286-95. doi: 10.1016/S2213-8587(14)70225-6. Epub 2015 Jan 13.

  PMID: 25591468 BACKGROUND

• Leung AM, Braverman LE. Consequences of excess iodine. Nat Rev Endocrinol. 2014 Mar;10(3):136-42. doi: 10.1038/nrendo.2013.251. Epub 2013 Dec 17.

  PMID: 24342882 BACKGROUND

• Li Y, Teng D, Ba J, Chen B, Du J, He L, Lai X, Teng X, Shi X, Li Y, Chi H, Liao E, Liu C, Liu L, Qin G, Qin Y, Quan H, Shi B, Sun H, Tang X, Tong N, Wang G, Zhang JA, Wang Y, Xue Y, Yan L, Yang J, Yang L, Yao Y, Ye Z, Zhang Q, Zhang L, Zhu J, Zhu M, Ning G, Mu Y, Zhao J, Shan Z, Teng W. Efficacy and Safety of Long-Term Universal Salt Iodization on Thyroid Disorders: Epidemiological Evidence from 31 Provinces of Mainland China. Thyroid. 2020 Apr;30(4):568-579. doi: 10.1089/thy.2019.0067. Epub 2020 Mar 24.

  PMID: 32075540 BACKGROUND

• Miller JC, MacDonell SO, Gray AR, Reid MR, Barr DJ, Thomson CD, Houghton LA. Iodine Status of New Zealand Elderly Residents in Long-Term Residential Care. Nutrients. 2016 Jul 23;8(8):445. doi: 10.3390/nu8080445.

  PMID: 27455319 BACKGROUND

• Laurberg P, Cerqueira C, Ovesen L, Rasmussen LB, Perrild H, Andersen S, Pedersen IB, Carle A. Iodine intake as a determinant of thyroid disorders in populations. Best Pract Res Clin Endocrinol Metab. 2010 Feb;24(1):13-27. doi: 10.1016/j.beem.2009.08.013.

  PMID: 20172467 BACKGROUND

• Limanova Z. [Thyroid disease in the elderly]. Vnitr Lek. 2018 Winter;64(11):993-1002. Czech.

  PMID: 30606015 BACKGROUND

• Zhai X, Zhang L, Chen L, Lian X, Liu C, Shi B, Shi L, Tong N, Wang S, Weng J, Zhao J, Teng X, Yu X, Lai Y, Wang W, Li C, Mao J, Li Y, Fan C, Li L, Shan Z, Teng W. An Age-Specific Serum Thyrotropin Reference Range for the Diagnosis of Thyroid Diseases in Older Adults: A Cross-Sectional Survey in China. Thyroid. 2018 Dec;28(12):1571-1579. doi: 10.1089/thy.2017.0715. Epub 2018 Nov 27.

  PMID: 30351201 BACKGROUND

• Barbesino G. Thyroid Function Changes in the Elderly and Their Relationship to Cardiovascular Health: A Mini-Review. Gerontology. 2019;65(1):1-8. doi: 10.1159/000490911. Epub 2018 Jul 20.

  PMID: 30032140 BACKGROUND

• Iacone R, Iaccarino Idelson P, Russo O, Donfrancesco C, Krogh V, Sieri S, Macchia PE, Formisano P, Lo Noce C, Palmieri L, Galeone D, Rendina D, Galletti F, Di Lenarda A, Giampaoli S, Strazzullo P, On Behalf Of The Minisal-Gircsi Study Group. Iodine Intake from Food and Iodized Salt as Related to Dietary Salt Consumption in the Italian Adult General Population. Nutrients. 2021 Sep 30;13(10):3486. doi: 10.3390/nu13103486.

  PMID: 34684487 BACKGROUND

• Jin Q, Wang Z, Li J, Zhang H, Liu M, Wang C, Guo W, Zhang W. Iodine Excess Is Associated with Thyroid Dysfunction Among the Elderly. Biol Trace Elem Res. 2025 Jul;203(7):3470-3478. doi: 10.1007/s12011-024-04420-0. Epub 2024 Oct 23.

  PMID: 39441230 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

1.Urinary iodine concentration was measured by collecting spot urine and 24-h urine samples. 2.Blood samples were collected to evaluate thyroid function. 3.Thyroid B-ultrasonography was conducted to measure the thyroid volume and thyroid nodule. 4.Saliva samples were collected to measure saliva iodine. 5.The iodine dietary frequency questionnaire was used to assess the long-term iodine intake level of the subjects.

MeSH Terms

Conditions

Thyroid Diseases

Condition Hierarchy (Ancestors)

Endocrine System Diseases

Study Officials

• Wenxing Guo, Doctor

  Public Health School, Tianjin Medical University

  STUDY CHAIR

Central Study Contacts

Wenxing Guo, Doctor

CONTACT

(86)18822024500; guowenxing@tmu.edu.cn

Zhangzhao Wang, Doctor

CONTACT

(86)13821470215; graik.wang@163.com

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer

Study Record Dates

• First Submitted: December 21, 2022
• First Posted: February 8, 2023
• Study Start: February 17, 2023
• Primary Completion: June 1, 2025
• Study Completion: December 30, 2025
• Last Updated: August 16, 2023

Record last verified: 2023-08

Locations

CN (3)