The Physiologic Effect of the Flow Generated by High Flow Nasal Cannula in Mild Respiratory Failure

NCT05708287 | Completed

• 1 other identifier: HMO-20-0260
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

High flow nasal cannula (HFNC) oxygen therapy is increasingly used for hypoxemic respiratory failure and is proving useful in avoiding or delaying intubation and mechanical ventilation. However, basic information regarding the physiologic effects of this method is missing. In this study, the effects of oxygen delivery by HFNC on oxygenation, ventilation and cardiovascular vital signs in patients with mild hypoxemic respiratory failure were evaluated.

Conditions

Respiratory Failure

Keywords

high flow nasal cannula; oxygenation; ventilation; conventional oxygen therapy; Arterial Blood Gasses

Outcome Measures

Primary Outcomes (2)

• The effect of changing flow rates generated by HFNC on oxygenation parameters of 28 patients with mild respiratory failure

  Change in PaO2 in mmHg(Partial pressure of oxygen in arterial blood) from baseline on nasal cannula and after giving gradually increasing flow rates to 60 Liters Per Minute on HFNC, at constant FiO2 of 40%.

  60 minutes

• The effect of changing flow rates generated by HFNC on ventilation parameters of 28 patients with mild respiratory failure

  Change in PaCO2 in mmHg(Partial pressure of carbon dioxide in arterial blood) from baseline on nasal cannula and after giving gradually increasing flow rates to 60 Liters Per Minute on HFNC, at constant FiO2 of 40%.

  60 minutes

Study Arms (1)

all patients

EXPERIMENTAL

Device: HFNC

Interventions

HFNC DEVICE

The patients with mild hypoxemia, defined as the need for conventional oxygen therapy (COT) using nasal cannula at 4-5 liters per minute (LPM) to maintain O2 Saturation \>90%, were commenced on HFNC therapy

all patients

Eligibility Criteria

• Age: 18 Years - 120 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Minimal age 18
• The patient had invasive blood pressure monitoring via an arterial line in situ
• The patient had a mild respiratory failure manifested by the need for oxygen support via nasal prongs in order to maintain oxygen saturation (SpO2) above 90% for at least one hour prior to the start of the intervention

You may not qualify if:

• Shortness of breath
• Patients regularly using O2 at home
• No patient consent for participation

Sponsors & Collaborators

• Hadassah Medical Organization: lead

Study Sites (1)

Hadassah medical center

Jerusalem, Israel

Location

MeSH Terms

Conditions

Respiratory Insufficiency; Respiratory Aspiration

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 14, 2022
• First Posted: February 1, 2023
• Study Start: August 1, 2020
• Primary Completion: December 31, 2020
• Study Completion: December 31, 2020
• Last Updated: February 1, 2023

Record last verified: 2022-12

Locations

IL (1)