Features of Regional Perfusion of Lung Consolidation

NCT05647967 | Unknown DMC

• 1 other identifier: I-22PJ140
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to evaluate the potential usefulness of lung ultrasound to assess the size and perfusion of consolidation and explore their relationships with clinical outcome.

Conditions

Lung Injury, Acute; Ultrasound Therapy; Complications

Keywords

lung consolidation, respiratory failure, perfusion

Outcome Measures

Primary Outcomes (2)

• consolidation area index

  The volume of consolidation was measured by consolidation area index (CAI) which is calculated from two-dimensional measures, namely the product of the core distance (from the bottom to the top of the screen) and the longitudinal distance (from the left to the right of the screen).

  through study completion, an average of 2 year

• blood flow score

  A semi-quantified scoring system based on the richness of flow signals was established. It identifies four progressive steps of blood signals, each corresponding to a score: no pulsatile blood flow-score 0; sparse dot-like blood flow-score 1; pronounced curvilinear vascularity-score 2; tree-like vascularity-score 3.

  through study completion, an average of 2 year

Study Arms (1)

the consolidation perfusion/the consolidation size

Patients with respiratory failure and lung consolidation proved by chest imaging underwent lung ultrasound to evaluate the regional perfusion and the size of consolidation.

Diagnostic Test: Ultrasound

Interventions

Ultrasound DIAGNOSTIC_TEST

Each patient underwent ultrasound after admission of ICU.

the consolidation perfusion/the consolidation size

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consisted of adult(\>18yr) patients admitted to the ICU. Patients presented with acute respiratory failure and pulmonary consolidation by chest imaging (lung ultrasound, X ray or CT scan) were eligible for inclusion. Acute respiratory failure was defined by at least one of the following criteria: PaO2/FiO2\<300mmHg, breathing frequencies\>30 breath/min, and could involve many potential causes of hypoxemia (e.g., sepsis, atelectasis, pneumonia, acute exacerbation of chronic lung disease).

You may qualify if:

• Admission to ICU( 18yr\<age\<90yr);
• Patients presented with acute respiratory failure;
• Pulmonary consolidation by chest imaging (lung ultrasound, X ray or CT scan).

You may not qualify if:

• Hemodynamic instability (i.e., severe hypotension with systolic arterial pressure\<60mmHg despite fluid expansion and vasoactive support; systolic arterial pressure\>180mmHg; uncontrolled cardiac arrhythmias);
• Severe thoracic trauma;
• Coronavirus disease 2019;
• Pulmonary artery hypertension and pregnancy.

Sponsors & Collaborators

• Peking Union Medical College Hospital: lead

Study Sites (1)

Peking union medical college hospital

Beijing, Beijing Municipality, 100010, China

RECRUITING

Related Publications (1)

• Wang N, Chi Y, Wang Q, Long Y, Liu D, Zhao Z, He H. Relationship between lung consolidation size measured by ultrasound and outcome in ICU patients with respiratory failure. BMC Pulm Med. 2025 Feb 26;25(1):91. doi: 10.1186/s12890-025-03564-6.

  PMID: 40011857 DERIVED

MeSH Terms

Conditions

Acute Lung Injury; Respiratory Insufficiency

Interventions

Ultrasonography

Condition Hierarchy (Ancestors)

Lung Injury; Lung Diseases; Respiratory Tract Diseases; Respiration Disorders

Intervention Hierarchy (Ancestors)

Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Officials

• Huaiwu He, MD

  Peking Union Medical College Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Na Wang, MD

CONTACT

17810258960; wangna_pumch2017@163.com

Huaiwu He, MD

CONTACT

010-69152300; timuhhw@126.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 29, 2022
• First Posted: December 13, 2022
• Study Start: January 1, 2022
• Primary Completion: December 31, 2023
• Study Completion: January 31, 2024
• Last Updated: December 13, 2022

Record last verified: 2022-11

Locations

CN (1)